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1999 Fiscal Year Final Research Report Summary

Molecular mechanism for zone-to-zone projection of axons

Research Project

Project/Area Number 09480234
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neuroscience in general
Research InstitutionUniversity of Tokyo (1999)
The Institute of Physical and Chemical Research (1997-1998)

Principal Investigator

MORI Kensaku  Graduate School of Medicine, University of Tokyo, Professor, 大学院・医学系研究科, 教授 (60008563)

Co-Investigator(Kenkyū-buntansha) NAGAO Hiroshi  Graduate School of Medicine, University of Tokyo, Assistant Professor, 大学院・医学系研究科, 助手 (50281647)
Project Period (FY) 1997 – 1999
KeywordsOCAM / Zone / Axonal projection / Olfactory Bulb / Purkinje cells
Research Abstract

We found a novel cell adhesion molecule OCAM. OCAM was expressed by olfactory sensory neurons in zones 2-4 but not by those in zone 1 of the nasal epithelium. OCAM-expressing olfactory axons projected selectively to ventrolateral zones of the main olfactory bulb. This indicates a "zone-to-zone projection" of olfactory axons. Tracing of olfactory axons expressing OCAM, neuropilin-1, or BIG-2 indicated that there exists a Precise correspondence between "cell adhesion molecule map" and "odorant receptor map" in the main olfactory bulb. In the accessory olfactory system, OCAM was expressed by apical zone sensory neurons but not by basal zone sensory neurons in the vomeronasal sensory epithelium. OCAM-expressing axons projected selectively to the rostral zone of the accessory olfactory bulb (AOB), indicating the "zone-to-zone projection" of vomeronasal axons. In the embryonic and early postnatal mice, OCAM was expressed selectively by mitral/tufted cells in the caudal zone of the AOB. Analyses with cell adhesion molecules suggested the existence of "pheromone receptor map" in the AOB. In cerebellar cortex. of late embryonic and early postnatal mice, OCAM was expressed selectively. by a subset of Purkinje cells, which were distributed within parasagittal zones. Using the homologous recombination method, we generated mice that lack OCAM I gene. We are now analyzing the and maintenance of the OCAM-deficient mice to examine the role of OCAM in the formation and maintenance of the zone-to-zone projection in the brain.

  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] von Campenhausen,H.他: "OCAM reveals segregated mitral/tufted cell pathways in developing accessory olfactory bulb"Neuro Report. 8. 2607-2612 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoshihara,Y.他: "OCAM:A new member of the newral cell adhesion molecule family related to zone-to-zone projection of olfactory and vomeronasal axons"J.Newroscience. 17. 5830-5842 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mori,K.他: "Computation of molecular information in mammalian olfactory systems"Network:Comput.Neural Syst.. 9. 79-102 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kashiwadani,H.他: "Synchronized oscillatory discharges of mitral/tufted cells with different molecular receptive ranges in the rabbit olfactory bulb"J.Neurophysiol.. 82. 1786-1792 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mori,K.他: "The olfactory bulb:coding and processing of odor molecule information"Science. 286. 711-715 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoshihara,Y.他: "A genetic approach to visualization of multi-synaptic neural pathways using plant lectin transgene"Neuron. 22. 33-41 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mizuno,T.他: "Newronal odhesion molecule telencephalin induces rapid cell spreading of microglia"Brain Res.. 849. 58-66 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Arii,N他: "Development of telencephalin in human cerebrum"Microscop.Res.Tech.. 46. 18-23 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] von Campenhansen,H.他: "Convergence of segregated pheromcnal pathways from the accessory olfactory bulb to the cortex in the mouse"Eur.J.Neurosci.. 12. 1-14 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Non Camenhausen, H.: "Convergence of segregated pheromenal pathways from the accessory olfactory bulb to the cortex in the mouse"Eur. J. Neurosci.. 12. 1-14 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] von Campenhausen, H., Yoshihara, Y., and Mori, K.: "OCAM reveals segregated mitral/tufted cell pathways in developing accessory bulb"Neuro Report. 8. 2607-2612 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshihara, Y., Kawasaki, M., Tamada. A., Fujita. H., Hayashi H., Kagamiyama, H., and Mori K.: "OCAM : A new member of the neural cell adhesion molecule family related to zone-to-zone projection of olfactory and vomeronasal axons"J. Neuroscience.. 17. 5830-5842 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshihara, Y. and Mori, K.: "Basic principles and molecular mechanisms of olfactory axon pathfinding"Cell Tissue Res.. 290. 457-463 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mori, K., Nagao, H., and Sasaki, Y. F.: "Computation of molecular information in mammalian olfactory systems"Network : Comput. Neural Syst.. 9. R79-R102 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kashiwadani, H., Sasaki, Y., Uchida. N., and Mori. K.: "Synchronized oscillatory discharges of mitral/tufted cells with different molecular receptive ranges in the rabbit olfactory bulb"J. Neurophysiol.. 82. 1786-1792 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mori, K., Nagao, H., and Yoshihara, Y.: "The olfactory bulb: coding and processing of odor molecule information"Science. 286. 711-715 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshihara Y., Mizuno T., Nakahira M., Kawasaki, M., Watanabe, Y., Kagamiyama, H., Jishage K., Ueda O., Suzuki. H., Tabuchi. K., Sawamoto. K., Okano H., Noda T., and Mori K.: "A genetic approach to visualization of multi-synaptic neural pathways using plant lectin transgene"Neuron. 22. 33-41 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mizuno, T., Yoshihara, Y., Kagamiyama, H., Ohsawa, K., Imai, Y., Kohsaka, S., and Mori, K.: "Neuronal adhesion molecule telencephalin induces rapid cell spreading of microglia"Brain Res.. 849. 58-66 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Arii, N., Mizuguchi, M., Mori, K. and Takashima, S.: "Development of telencephalin in human cerebrum."Microscop. Res. Tech.. 46. 18-23 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Von Campenhausen H. and Mori, K.: "Convergence of segregated pheromonal pathways from the accessory olfactory bulb to the cortex in the mouse"Eur. J. Neurosci.. 12. 1-14 (2000)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2001-10-23  

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