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1998 Fiscal Year Final Research Report Summary

Steric visualization of diseased organs of laboratory small animals by three-dimensionally reconstructing MRI method

Research Project

Project/Area Number 09556064
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Applied veterinary science
Research InstitutionHOKKAIDO UNIVERSITY

Principal Investigator

KUWABARA Mikinori  Grad.School of Vet.Med., Hokkaido Univ.Pro., 大学院・獣医学研究科, 教授 (10002081)

Co-Investigator(Kenkyū-buntansha) SHIMOKAWA Shigezo  Technoscience Lab.Co., Seni.Sci., 主任研究員
KON Yasuhiro  Grad.School of Vet.Med., Hokkaido Univ.Asso.Pro., 大学院・獣医学研究科, 助教授 (10178402)
ARIKAWA Jiro  Hokkaido Univ.School of Med., Pro., 医学部, 教授 (10142704)
YAMAMOTO Tsuyoshi  Computer Center, Hokkaido Univ.Pro., 大型計算機センター, 教授 (80158287)
INANAMI Osamu  Grad.School of Vet.Med., Hokkaido Univ.Asso.Pro., 大学院・獣医学研究科, 助教授 (10193559)
Project Period (FY) 1997 – 1998
KeywordsMRI / three-dimensional steric image / laboratory small animal / model diseases / mouse lung tumor / mouse liver tumor / volume rendering / contrast agent
Research Abstract

Using multislice MT images of thoracic and abdominal organs in laboratory small animals, three-dimensional (3-d) images were constructed by superimposing them on the computer with the volume ray tracing software. Positive contrast agent was orally administrated into stomach and duodenum cavities just before MR.imaging. Two-dimensional transversal multislices of MR images from thoracic to abdominal regions were taken by an SIS300/183 MRI system with a magnetic field of 7.05 T under the proton-weighting condition (TR=2000ms, TE=20ms). The slice thickness was I mm and the multislice spin-echo method was employed. Each organs (stomach, liver, duodenum, spleen, kidney heart, born and spine) was pseudo-colored by the commercially available graphic software Adobe Photoshop. The 3-d images were then constructed by superimposing these colored-multislices on a UNIX computer by the volume ray tracing method . In rats and mice, the thoracic and abdominal organs were visualized as the pseudo-colored 3-d MR images. The transparent 3-d images were also constructed which made us possible to clearly distinguished individual organ from other organs with respect the position, size and shape. Furthermore, the pathological changes of tissues could be recognized by this 3-d MRI technique in BALB/c mice with liver tumors derived from colon-26 cell line and in A/J mice with lung tumors induced by urethan.

  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] Taketoshi Asanuma: "Magnetic resonance imaging of hepatocellular carcinoma in Long-Evans Cinnamon rat under a magnetic field of 7.05 T" Japanese Journal of Veterinary Research. 45・3. 147-151 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 浅沼 武敏: "実験小動物の7.05T MRI (磁気共鳴断層撮像法)" 放射線科学. 40・7. 221-227 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Taketoshi Asanuma: "Visualization of the topographical structure of the anesthetized mouse brain by MR microimaging" Journal of Veterinary Medical Science. 60・12. 1311-1314 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Taketoshi Asanuma: "MR imaging of hepatic injury in the LEC rat under a high magnetic field (7.05T)" Journal of Veterinary Medical Science. 61・3. 239-244 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mikinori Kuwabara: "Biodefense Mechanisms against Environmental Stress" T. Ozawa, K. Tatsumi and T. Hori, 10 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Asanuma, T., Hirano, Y., Ohkura, K., Kon, Y., Shimokawa, S., Kasai, N.and Kuwabara, M.: "Magnetic resonance imaging of hepatocellular carcinoma in Long-Evans Cinnamon rat under a magnetic field of 7.05 T" Japanese Journal of Veterinary Research. 45 (3). 147-151 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Asanuma, T.and Kuwabara, M.: "7.05 T MRI of laboratory small animals (in Japanese)" Radiological Sciences. 40 (7). 221-227 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Asanuma, T., Shimokawa, S., Inanami, O., Kon, Y.and Kuwabara, M.: "Visualization of the topographical structure of the anesthetized mouse brain by MR microimaging" Journal of Veterinary Medical Science. 60 (12). 1311-1314 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Asanuma, T., Hirano, Y., Yamamoto, K., Kon, Y., Shimokawa, S.and Kuwabara, M.: "MR imaging of hepatic injury in the LEC rat under a high magnetic field (7.05T)" Journal of Veterinary Medical Science. 61 (3). 239-244 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kuwabara, M.and Inanami, O.: Biodefense against active oxygens and free radicals induced by oxidative stress, Biodefense Mechanisms against Environmental Stress. Ozawa, T., Tatsumi, K.and Hori, T.eds., Kodansha and Springer, Tokyo, 23-32 (1998)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-12-08  

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