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1998 Fiscal Year Final Research Report Summary

Development of novel gene therapies in the field of liver surgery

Research Project

Project/Area Number 09557104
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Digestive surgery
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

ARII Shigeki  Kyoto Univ., Faculty of Medicine, A.P., 医学研究科, 助教授 (50151171)

Co-Investigator(Kenkyū-buntansha) KAIDO Toshimi  Kyoto Univ., Faculty of Medicine, Associate, 医学研究科, 助手 (80314194)
IMAMURA Masayuki  Kyoto Univ., Faculty of Medicine, P., 医学研究科, 教授 (00108995)
Project Period (FY) 1997 – 1998
Keywordsliver Surgery / gene therapy / VEGF / p53 / cre-loxp / Flt-1 / IL-12
Research Abstract

There are many diseases and pathophysiological status for the liver surgery. Particulary, the most frequent diseases in this field are primary and secondary liver cancers. Furthermore, novel strategies against the liver failure due to various causes should be also resolved.
In the present study, we attempted to develop new strategies against. The above diseases by gene therapies.
We obtained the following results which included the development of the gene therapies in the fields other than liver surgery.
1) We clarified the efficacy of VEGF gene therapy for prevention of sinusoidal endothelial cell damage during cold preservation.
2) We clarified the efficacy of VEGF gene therapy-for prevention of endotoxin induced liver failure.
3) We developed P53 expression of suicide gene with on/off switch by CreィイD1-ィエD1loxp system.
4) We developed gene therapy using soluble Flt-1 expression vector for peritoneal dissemination of cancer.
5) We developed immunogene therapy by using IL-12 gene transfected dendritic cells

  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] A.Mori: "Soluble Flt-1 gene therapy for peritoneal metastases using HVJ-cationic liposomes"Gene Therapy. (in press).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Furumoto: "Spleen-derived dendritic cells engineered to enhance interleukin-12 production elicit therapevtic antitumor immune responses"Int J Cancer. (in press).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] MJ.Gorrin-Rives: "Macropage metalloelastase gene transfer into melanoma cells suppresses primary tomor growth by halting angiogenesis"Clinical Cancer Res. (in press).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 森 章: "HVJ-Cationic liposomeによる肝類洞壁細胞および肝癌細胞に対する遺伝子導入の試み"肝類洞壁細胞研究の進歩. 10. 131-133 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 森 章: "胃癌腹膜播腫モデルに対するsolble Flt-1遺伝子治療"消化器科. 30. 46-51 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 森 章: "可溶性Flt-1による腫瘍血管新生の制御"分子がん治療. (in press).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] A. Mori: "Soluble Flt-1 gene therapy for peritoneal metastasis using HVJ-cationic liposomes"Gene Therapy. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Furumoto: "Spleen-derived dendritic cells engineered to enhance interleukin-12 production elicit therapeutic antitumor immune responses"Int J Cancer. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] MJ. Gorrin-Rives: "Macropage metalloelastase gene transfer into melanoma cells suppresses primary tumor growth by halting angiogenesis"Clinical Cancer Res. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] A. Mori: "Gene transduction to hepatic sinusoidal cell and hepatic cancer using HVJ-catimic liposome"Progress in Hepatic Sinusoidal Cell Studies. Vol.10. 131-133 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] A. Mori: "Soluble Flt-1 gene therapy for peritoneal metastasis"Gastroenterology. Vol.30. 46-51 (2000)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2001-10-23  

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