• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1999 Fiscal Year Final Research Report Summary

Development of Vitreal Drug Delivery System with Biodegradable Polymeric Scleral Plug

Research Project

Project/Area Number 09557137
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Ophthalmology
Research InstitutionNagoya City University

Principal Investigator

OGURA Yuichiro  Nagoya City University Medical School, Professor, 医学部, 教授 (70191963)

Co-Investigator(Kenkyū-buntansha) OHATA Atsutoshi  Santen Pharmaceutical Co., 眼科動態研究グループ, グループ長
SAKURAI Eiji  Nagoya City University Medical School, Instructor, 医学部, 助手 (30305528)
OZEKI Hironori  Nagoya City University Medical School, Assistant Professor, 医学部, 講師 (60254299)
TAMAI Kazushi  Nagoya City University Medical School, Assistant Professor (40188412)
SHIRAI Shoichiro  Nagoya City University Medical School, Associate Professor (30080063)
Project Period (FY) 1997 – 1999
Keywordsdrug delivery system / biodegradable polymer / vitreous / retina / sclera / 硝子体
Research Abstract

We have developed a novel drug delivery system in the vitreous body with the use of biodegradable polymers. Scleral plugs made of biodegradable polymers implanted at the pars plana were evaluated to determine its ability to control the intravitreal release of drugs. Scleral plugs containing various drugs, such as ganciclovir, 5-fluorouracil, and fluconazol, were prepared with poly(lactic-glycolic acid). Drug release from the plugs was studied in vitro as well as in vivo using rabbits and monkeys. Biocompatibility of the scleral plugs was also evaluated in rabbits and monkeys. The in vitro studies showed the plugs released the drugs for several weeks to several months. The in vivo studies showed the drug concentrations were maintained at effective ranges for certain period of time after the implantation of the plugs. No significant adverse reactions were observed in the ocular tissues both clinically and histologically.
These results suggested that scleral plugs of biodegradable polymers are promising for a controlled drug delivery system in the vitreous.

  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] Miyamoto H, et al: "Suppression of experimental conreal angiogenesis by focal X-ray Irradiation"Current Eye Research. 19. 53-58 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yasukawa T, et al: "Targcted delivery of anii-angiogenic agent TNP-470 using water-soluble polymer in the ireatment of choroidal neovascularizaiton"Invest Ophthalmol Vis Sci. 40. 2690-2696 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Miyamoto H, et al: "Effect of focal X-ray irradiation on experimental choroidal neovascularization"Invest Ophthalmol Vis Sci. 40. 1496-1502 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hashizoe M, Ogura Y, takanashi T, Kunou N, Honda Y, Ikada Y: "Biodegradable polymeric device for sustained intravitreal release of ganciclovir in rabbits."Current Eye Research. 16. 633-639 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Miyamoto H, Ogura Y, Hashizoe M, Kunou N, Honda Y, Ikada Y: "Biodegradable scleral implant for intravitreal controlled release of fluconazol."Current Eye Research. 16. 930-935 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yasukawa T, Kimura H,Tabata Y, Miyamoto H, Honda Y, Ikada Y, Ogura Y: "Targeted delivery of anti-angiogenic agent TNP-470 using water-soluble polymer in the treatment of choroidal neovascularization."Investigative Ophthalmology & Visual Science. 40. 2690-2696 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Miyamoto H, Kimura H, Yasukawa T, Yang C, Honda Y, Tabata Y, Ikada Y, Sasai K, Ogura Y: "Suppression of experimental corneal angiogenesis by focal X-ray irradiation."Current Eye Research. 19. 53-58 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Miyamoto H, Kimura H, Yasukawa T, Honda Y, Tabata Y, Ikada Y, Sasai K, Ogura Y: "Effect of focal X-ray irradiation on experimental choroidal neovascularization."Investigative Ophthalmology & Visual Science. 40. 1496-1502 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kimura H, Spee C, Sakamoto T, Hinton D R, Ogura Y, Tabata Y, Ikada Y, Ryan S J: "Cell response in subretinal neovascularization induced by bFGF-impregnated microspheres."Investigative Ophthalmology & Visual Science. 40. 524-528 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yasukawa T, Kimura H, Kuhou N, Miyamoto H, Honda Y, Ogura Y, Ikada Y: "biodegradable scleral implant for intravitreal controlled release of ganciclovir."Grafe's Archive for Clinical and Experimental Ophthalmology. 238. 186-190 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yang CF, Yasukawa T, Kimura H, Miyamoto H, Honda Y, Tabata Y, Ikada Y, Ogura Y: "Experimental corneal neovascularization by basic fibroblast growth factor incorporated into gelatin hydrogel."Ophthalmic Research. 32. 19-24 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kunou N, Ogura Y, Honda Y, Hyon SH, Ikada Y: "Biodegradable scleral implant for controlled intraocular drug delivery of betamethasone phosphate."J Controlled Release. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sakurai E, Ozeki H, Kunou N, Ogura Y: "Evaluation of polymeric nanospheres as a controlled drug delivery system to the retina and vitreous."Ophthalmic Research. (in press).

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 2001-10-23  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi