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2000 Fiscal Year Final Research Report Summary

Development of Analytical Method of Oral Function in Masticational Cycle.

Research Project

Project/Area Number 09557154
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section展開研究
Research Field Conservative dentistry
Research InstitutionKyoto Prefectural University of Medicine(KPUM)

Principal Investigator

HORI Nobutaka  KPUM, Dept.of Med., Professor, 医学部, 教授 (10067019)

Co-Investigator(Kenkyū-buntansha) BABA Shunsuke  KPUM, Dept.of Med., assistant Professor, 医学部, 助手 (40275227)
KANAMURA Narisato  KPUM, Dept.of Med., lecturer, 医学部, 助手 (70204542)
TSUKITANI Kouji  KPUM, Dept.of Med., lecturer, 医学部, 講師 (10121328)
UCHIYAMA Tatsumi  NEC Medical System Co.Ltd.
Project Period (FY) 1997 – 2000
Keywordsoral function / mastication / mandibular movements / brain activation / functionl MRI / MEG
Research Abstract

Masticatory movements is fundamentally characterized by its repeated rhythmical movements, and the rhythm of mastication is known to be controlled by the rhythm generator that exists in the central nervous system. Furthermore, sensory information from the peripheral nerve is also involved in controlling motor function in the masticatory system, which is thought to be the essence of the neuromuscular coordination related to the masticatory system. Although mapping of the area activated during a series of masticatory movements within the primary sensorimotor area known to control mandibular movement as well as sensation has previously been reported, changes in the activation state by clenching remains to be clarified. In this study, we examined the posibility of Development of analytical method of oral function in masticational cycle. Previous brain mapping studies on mastication were performed using positron emission tomography(PET), however, PET has a drawback concerning radiation exposure. Non-invasive functional magnetic resonance imaging(fMRI), which visualizes the functioning area in the brain, was use to determine blood oxygen level dependent(BOLD) signals, which are regarded as an index of functionally induced changes in the cerebral regional blood flow. Measurements of fMRI were performed on a conventional whole body 1.5T clinical scanner using a single shot, multislice echo-planar imaging sequence. And MEG were performed for determine cortex reaction of trigeminal nerve for lower lip. Six normal volunteers underwent fMRI and MEG during biting and favorite food imaging task. Image processing was performed using all pixels with significant signal intensity(SI) change determined from the fMRI data and MEG data. The findings showed that the SI significantly increased by biting task and favorite food imaging task. These findings suggest that fMRI and MEG were very useful analytical method for oral function research.

  • Research Products

    (9 results)

All Other

All Publications (9 results)

  • [Publications] BABA S, FUKUNAGA M, TANAKA C, EBISU T, HORI N: "Effect of biting force on the activation of the brain in fMRI."J Dental Research. 78. 194 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 平野哲雄、高梨芳彰、吉川健治、岩本一秀、山本孝徳、大嶋英之、廣田明人、馬場俊輔、中島健二: "言語音(「あ」)と非言語音(ホワイトノイズ,純音1kHz)刺激による聴覚誘発脳磁場の検討;Lateralizationを中心に."生理学研究所年報. 78. 194 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] BABA S, HIROTA A, YOTSUI Y, TANAKA M, KAWAZOE T, HORI N: "Imaginary mastication cause primary sensorimotor cortex activation."J Dental Research. 79. 493 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 平野哲雄,高梨芳彰,岩本一秀,大嶋英之,廣田明人,馬場俊輔: "言語音刺激と非言語音刺激による聴覚誘発磁場反応の特徴."日本臨床神経生理学会雑誌. 28(2). 160 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 馬場俊輔,吉友有祐,廣田明人,田中昌博,川添堯彬,堀亘孝: "咀嚼の想像による大脳皮質の賦活状態."日本補綴歯科学会雑誌. 44. 146 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] NISHIDE N, BABA S, HORI N, NISHIKAWA H.: "Histological study of rat masseter muscle following experimental occlusal alteration"Journal of Oral Rehabilitation. 28(in press).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] BABA S, FUKUNAGA M, TANAKA C, EBISU T, HORI N: "Effect of biting force on the activation of the brain in fMRI."J Dental Research. Vol.78. 194 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] BABA S, HIROTA A, YOTSUI Y, TANAKA M, KAWAZOE T, HORI N: "Imaginary mastication causes primary sensorimotor cortex activation."J Dental Research. Vol.79. 493 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] NISHIDE N, BABA S, HORI N, NISHIKAWA H: "Histological study of rat masseter muscle following experimental occlusal alteration"Journal of Oral Rehabilitation. 28(in press).

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2002-03-26  

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