1998 Fiscal Year Final Research Report Summary
Correlation between Degree of Inhibition of Parasympathetic Reflex Vasodilation and MAC Value for Various Inhalation Anesthetics
| Project/Area Number |
09557161
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Surgical dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
IZUMI Hiroshi School of Dentistry, Tohoku University Assistant, 歯学部, 助手 (20108541)
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| Co-Investigator(Kenkyū-buntansha) |
IWATSUKI Naofumi Dental Hospital Tohoku University Professor, 歯学部・附属病院, 教授 (50004908)
SATO Minoru Dental Hospital Tohoku University Assistant, 歯学部・附属病院, 助手 (20235401)
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| Project Period (FY) |
1997 – 1998
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| Keywords | Inhalation / GABA / Parasympathetic / Vasodilatation / Autonomic / Correlationship |
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| Research Abstract |
The effects of various types of general anesthetics (isoflurane, propofol1 ketamine, pen-tobarbitone) on parasympathetic reflex vasodilatation were compared to investigate the involvement in their actions of GABA-mediated synaptic inhibition, enhancement of which is thought to underlie the action of many anesthetics agents. In urethane plus alpha-chloral-ose anaesthetized cats, parasympathetic reflex vasodilatation in the ipsilateral lower lip was elicited by electrical stimulation of the central cut end of the lingual nerve. Isofluraneand pentobarbitone both produced a marked dose-dependent inhibition of this vasodila-tor response. By contrast, propofol and ketamine had no effect on the parasympathetic reflex vasodilatation. The administration of a GABA-antagonist (picrotoxin) reversed the inhibitions produced by isoflurane (previous results) and pentobarbitone (the presentstudy). A dose-related inhibition of this response was induced by the inhalation anesthetics isoflurane, halothane, sevoflurane, and enflurane, the ID_<50> values being 0.94%, 0.82%, 1.74%, and 2.0%, respectively. These results indicate that the ID_<50> value isapproximately two-thirds of the published MAC value for such anesthetics, suggesting that parasympathetic reflex vasodilation is more susceptible than somato-somatic reflexes to inhibition by inhalation anesthetics.
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[Publications] Ito, Y., Izumi, H., Sato, M., Karita, K.and Iwatsuki, N.: "Suppression of parasympathetic reflex vasodilatation in the lower lip of the cat by isoflurane, propofol, ketamine and pentobarbital : impli-cations for mechanisms underlying the production of anaesthesia" Br.J.Anaesthesia. 81. 563-568 (1998)
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