1999 Fiscal Year Final Research Report Summary
Development of novel anti-inflammation and anti-rheumatism drugs
| Project/Area Number |
09557182
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 展開研究 |
|---|
| Research Field |
Chemical pharmacy
|
|---|
| Research Institution | University of Tokushima |
|---|
Principal Investigator |
KUWAHARA Jun The University of Tokushima, Faculty of Pharmaceutical Sciences, Associate Professor, 薬学部, 助教授 (90225318)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TANAKA Hirokazu Fujisawa Pharmaceutical Co., Ltd., Director, 新薬研究所, 所長
|
|---|
| Project Period (FY) |
1997 – 1999
|
| Keywords | iNOS / NO / Benzoquinone / Vitamin K3 / Triptoquinone |
|---|
| Research Abstract |
Nitric oxide (NO) plays an important role in diverse physiological processes, while induction of inducible NO synthease (iNOS) by various stimuli is responsible for pathogenesis of septic shock, and some inflammatory and auto immune diseases. Benzoquinone significantly inhibited NO production in rat C6-glia cell activated by LPS and IFN-γ. Inhibitory effect of benzoquinone might not simply be resulted from redox mechanism, because its two-electron reduced form, hydroquinone also strongly impaired NO production. Of special interest is it that vitamin K3 dramatically increases production of NO by the same stimuli. Mechanistic studies showed that vitamin K3 potentiates the expression of iNOS gene through increase of nuclear entry of NF-kB. In spite of their simple chemical structures, vitamin K3 and benzoquinone have contrary effects on iNOS gene expression. These facts would give useful information on rational design of an new anti-inflammatory and anti-rhymatism drug based on selective inhibition of iNOS activity.
|
-
-
-
-
-
-
-
-
[Publications] Saito, Y., Ishii, Y., Hayashi, H., Imao, Y., Akashi, T., Yoshikawa, K., Noguchi, Y., Soeda, S., Yoshida, M., Niwa, Y., Hosoda, J., Shimomura, K.: "Cloning of genes V coding for L-sorbose and L-sorbosone dehydrogenases from gluconobacter oxydans and microbial production of 2-keto-L-gulonate, a precursor of L-ascorbic acid, in a recombinant G.oxydans strain"Appl. Envir. Microbiol.. 63. 454-460 (1997)
Description
「研究成果報告書概要(欧文)」より
-
[Publications] Yamamoto, S., Kamada, M., Maegawa, M., Takikata, M., Nakaya, Y., Niwa, M., Aono, T.: "IL-1 α Induces inducible nitrix oxide synthase In uterine smooth muscle"Biochem. Biophys. Res. Commun.. 238. 12-16 (1997)
Description
「研究成果報告書概要(欧文)」より
-
[Publications] Niwa, M., Nakamura, N., Kitajima, K., Ueda, M., Tsutsumishita, Y., Futaki, S., Takaishi, Y.: "Benzoquinones inhibit the expression of inducible nitric oxide synthase gene"Biochem. Biophys. Res. Commun.. 239. 367-371 (1997)
Description
「研究成果報告書概要(欧文)」より
-
[Publications] Tsutsumishita, Y., Onda, T., Okada, K., Takeda, M., Endou, H., Futaki, S., Niwa, M.: "Involvement of H2O2 production in cisplatin-induced nephrotoxicity"Biochem. Biophys. Res. Commun.. 242. 310-312 (1998)
Description
「研究成果報告書概要(欧文)」より
-
