1999 Fiscal Year Final Research Report Summary
Studies on effector molecules of innate immunity responsible for cytotoxicity to tumor cells.
| Project/Area Number |
09557191
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Biological pharmacy
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| Research Institution | HOKKAIDO UNIVERSITY |
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Principal Investigator |
NAGASAWASHIGEHARU Hokkaido Univ., Grad Sch. Pharm. Sci., Pro., 大学院・薬学研究科, 教授 (70029958)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIMURA Haoshi Hokkaido Univ., Grad Sch. Pharm. Sci., Inst., 大学院・薬学研究科, 助手 (80241347)
YAMASHITA Toshiyuki Hokkaido Univ., Grad Sch. Pharm. Sci., Inst., 大学院・薬学研究科, 講師 (90192400)
TAKAHASHI Kazuhiko Hokkaido Univ., Grad Sch. Pharm. Sci., Lec., 大学院・薬学研究科, 助教授 (10113581)
SATO Noriyuki Sapporo Med. Univ., Sch. Med., Pro., 医学部, 教授 (50158937)
SEYA Tsukasa Osaka Med. Cent Cancer and Cardiovas. Diseases, Div. Head., 研究所, 部長 (10301805)
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| Project Period (FY) |
1997 – 1999
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| Keywords | Innate immunity / natural killer cells (NK) / tumor cells / cytotoxicity / complement / M. fermentans |
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| Research Abstract |
A. We found a novel negative regulator molecule, Cho-1, which is expressed on normal cells and protected host cells from the cytotoxicity by natural killer (NK) cells. Cho-1 was IFN-γ-inducible, but appeared to be different from MHC class I with respect to molecular composition and immunoreactivity. Although this molecule was expressed on certain tumor cell lines, it was not involved in the cytotoxic mechanism of CTL. Thus, Cho-1 appeared to be the novel regulatory molecule in the NK cytotoxic mechansim of innate
B. We found a M 161Ag, which is expressed on human malignant cells and induces homologous complement activaton. cDNA of M161Ag revealed that it is highly homologous to P48, my coplasma fermentans gene product It was revealed that latently infected M, fermentans allows human cells to produce M161Ag, which is a potent modulator of innate and cellular immune responses via its complement activating and cytokine-producing activity.
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[Publications] Akawa T., Hirohashi, Y., Kantguchi, K., Sahara, H., Torigoe, T., Nagasawa, S., and Satoh, N.: "A novel negative regulator molecule, Cho-1, is involved in the cytotoxicity by human natural killer cells but not in cytotoxic T lymphocytes."Microbiol. Immunol.. 43. 285-291 (1999)
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[Publications] Matsumoto. M., Takeda, J., Inoue, N., Hara, T., Hatanaka, M., Takahashi, K., Nagasawa. S., Akedo, H., and Seya, T.: "A novel Protein that partcipates in nonself discrimination of malignant cells by homologous complement."Nature-Medicine. 3. 1266-1270 (1997)
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[Publications] Matsumoto. M., Nishiguchi, M., Kikkawa, S., Nishimura, H., Nagasawa, S., and Seya, T.: "Structural and functional properties of complement-activ ating protein M161Ag, a micoplasma fermentans gene product that induces cytokine production by human monocytes."J. Biol. Chem.. 273. 12407-12414 (1998)
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「研究成果報告書概要(欧文)」より
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