1998 Fiscal Year Final Research Report Summary
Development of ultra-fast funcional MRI
| Project/Area Number |
09558101
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Neuroscience in general
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| Research Institution | Niigata University |
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Principal Investigator |
NAKADA Tsutomu Niigata University Brain Research Institute Professor, 脳研究所, 教授 (50281720)
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| Co-Investigator(Kenkyū-buntansha) |
TSUKAMOTO Tetsuji GE Yokogawa Advanced Technology Center Group Head, 技術開発センター, グループ長
KIRYU Toru Niigata University Graduate School of Science and Technology Professor, 大学院・自然科学研究科, 教授 (80115021)
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| Project Period (FY) |
1997 – 1998
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| Keywords | functional MRI / Movie system / 電流密度画像 |
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| Research Abstract |
Blood oxygenation level dependent (BOLD) contrast functional magnetic resonance imaging (MRI) has revolutionized the investigations of higher brain function in humans. Nevertheless, the method still has various shortcomings. Contrary to popular belief, BOLD-fMRI in the current form does not possess sufficient validity regarding temporal resolution. The projects are designed to further refine the BOLD-fMRI technique utilizing a high-field (3.OT) system, especially in the aspect of temporal resolution. Technical achievements of the project include (1) optimization of horizontal 3.0T system for BOLD-fMRI, (2) realization of various critical technologies necessary in the development of a vertical 3.0T system, and (3) synchronized analysis of fMRI and high-density (256 channel) EEG topography. The project has also yielded various neuroscientific findings, including the discovery of a premotor no-motion area, right hemisphere dominance in 3 dimensional visual information processing in humans, and lack of appropriate dorsolateral frontal lobe activation in schizophrenic patients during a working memory task.
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