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1999 Fiscal Year Final Research Report Summary

Recovery of localized brain function in learning disabled children -regional cerebral blood flow and cognitive-neuropsychological study-

Research Project

Project/Area Number 09610161
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 教育・社会系心理学
Research InstitutionNational Center of Neurology and Psychiatry (NCNP)

Principal Investigator

UNO Akira  National Center of Neurology and Psychiatry (NCNP), National Institute of Mental Health (NIMH), Department of Developmental Disorders, Head of Therapeutic Research Division, 精神保健研究所・知的障害部治療研究室, 室長 (10270688)

Co-Investigator(Kenkyū-buntansha) INAGAKI Masumi  National Center of Neurology and Psychiatry (NCNP), National Institute of Mental Health (NIMH), Department of Developmental Disorders, Head of Diagnostic Research Division, 精神保健研究所・知的障害部, 室長 (70203198)
KAGA Makiko  National Center of Neurology and Psychiatry (NCNP), National Institute of Mental Health (NIMH), Head of Department of Developmental Disorders, 精神保健研究所・知的障害部, 部長 (20142250)
Project Period (FY) 1997 – 1999
KeywordsLearning Disability (LD) / Regional cerebral blood flow (rCBF) / Cognitive Neuropsychology / Recovery
Research Abstract

Neuropsychological assessment batteries were used to detect higher brain dysfunction, and single photon emission tomography to measure regional cerebral blood flow (rCBF). 15 learning disabled (LD) children, with normal intellectual ability in psychological performance and no brain lesions detected by magnetic resonance imaging (MRI) or computed tomography, were examined from 1997 to 1999. They manifested specific cognitive disorders, namely, specific Kanji writing disorders, specific dyslexia with dysgraphia for Kanji, specific dyslexia with dysgraphia for both Kanji and Kana, and verbal semantic disorders. We supposed their dysfunction parts of their brain based on the place where rCBF is reduced compared with the contralateral area. Four of 15 children were evaluated twice for rCBF and cognitive neuropsychological abilities. As results, we found that the area with reduced rCBF in LD children correspond to the brain lesion in adults with an acquired brain damage showing similar symptoms. For example, all LD children who showed writing or reading disorders manifested reduced rCBF in their temporal and/or parietal lobe, and those showed verbal semantic disorders without non-verbal semantic disability, manifested reduced rCBF in their temporal lobe. These results suggest that LD is caused by a localized brain dysfunction.
Two children showed almost no changes of their cognitive-neuropsychological symptoms. One had specific Kanji writing disorder and the other had dyslexia with dysgraphia for both of Kanji and Kana. Their rCBF showed almost no changes in the reduced rCBF for two years. On the other hand, a child, who manifested verbal semantic disorder, showed improvement in cognitive neuropsychological performance and rCBF in the left temporal lobe.
Thus the change of cognitive neuropsychological performance and rCBF showed parallel in these LD children.

  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] 宇野彰,春原則子,金子真人,加我牧子,松田博史: "特異的言語機能障害児における非言語的認知能力の発達"音声言語医学. 40. 388-392 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] E.W.Yund, A.Uno, D.L.Woods: "Preattentive Control of Serial Auditory Processing in Dichotic Listening"Brain and Language. 66. 358-376 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 宇野彰,加我牧子,稲垣真澄,金子真人,春原則子: "特異的漢字書字障害児の認知能力に関する神経生理学的および神経心理学的発達"臨床脳波. 41(6). 392-396 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 春原則子,宇野彰,加我牧子,松田博史,金子真人: "Semantic-pragmatic disordersの一例における言語性の意味理解障害について-音韻処理過程と意味処理過程との乖離-"脳と発達. 31(4). 370-375 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 宇野彰: "学習障害の神経心理学的解析-神経心理症状と局所脳血流低下部位との対応-"脳と発達. 31(3). 237-243 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 宇野彰,堀口寿広,山田裕康,加我牧子: "学習障害(LD)児および周辺児・者の日常生活におけるハンディキャップに関する調査研究-各都道「LD親の会」代表者からの回答-"

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 加我牧子,宇野彰: "わかるLDシリーズ LDと治療(日本LD学会編 : 中根彰,加藤醇子責任編集)"日本文化科学社. (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 加我牧子,稲垣真澄,宇野彰: "小児の言葉の障害"医歯薬出版. (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Uno A,: "Neuropsychological approach to the learning disability: the correlation between Neuropsychological findings and rCBF"No to Hattatsu. 31. 237-243 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Uno A, Haruhara N, Kaneko M, Kaga M, Matsuda H,: "Development of non-linguistic cognitive ability in specific language impairment children"The Japan Journal of Logopedics and Phoniatrics. 40. 388-392 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Uno A, E.W.Yund, D.L.Woods: "Preattentive control of serial auditory processing in dichotic listening"Brain and Language. 66. 358-376 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Uno A, Kaga M, Inagaki M, Kaneko M, Haruhara N,: "Neurophysiological and neuropsychological development of cognition in a specific Kanji writing disabled child"Clinical Electroencephalography. 41(6). 392-396 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Uno A, Horiguchi T, Yamada H, Kaga M,: "Assessment of handicaps of learning disabled (LD) children or its related conditions in their daily life: Response of 47 representative of association for parents of LD"Psychiatria et neurologia paediatrica Japonica. 39(1). 73-78 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Uno A, Haruhara N, Kaga M, Matsuda H, Kaneko M: "Deficit of language comprehension in a child with semantic - Pragmatic disorder - Disassociation between the phonemic and semantic processing abilities"No to Hattatsu. 31(4). 370-375 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kaga M, Uno A,: "Brain function and Learning, in LD and Treatment (ed. Nakane A, Kato J)"Nihon Bunka Kagakusha. 47-60 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kaga M, Inagaki M, Uno A: "Language Disorder in Children"Ishiyaku shuppan. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2001-10-23  

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