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1999 Fiscal Year Final Research Report Summary

Study of separation based on the complexation of boron compouunds for neutron capture therapy by using zone electrophoresis.

Research Project

Project/Area Number 09640725
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 分離・精製・検出法
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

KITAOKA Yoshinori  Research Reactor Institute, KYOTO UNIVERSITY Assistant Professor., 原子炉実験所, 助教授 (00027426)

Co-Investigator(Kenkyū-buntansha) 北岡 祥伯  京都大学, 原子炉実験所, 助教授 (00027426)
Project Period (FY) 1997 – 1999
KeywordsZone Electrophoresis / p-Boronophenylalanine / Oxalate / Citrate / lsocitrate / Tyrosine / p-Boronoserine / Phenylalanine
Research Abstract

The observed migration on zone electrophoresis is a summation of capillary action, electro-osmotic flow and electrophoretic movement. Electrophoretic behavior of p-boronophenylalanine (p-BPA) and its related compounds was studied under various electrophoresis conditions.
1. The migration distances of p-BPA, m-BPA and p-boronophenylserine (p-BPS) in acidic oxalate supporting solutions were compared with those of usual amino acids [Tyrosine (Tyr), Phenylalanine (Phe) and 3,4-dihydroxy phenylalanine]. p-BPA, m-BPA and p-BPS showed unusual anionic movements. p-BPA was specifically isolated from a mixture of Tyr, Phe and p-BPA by using a oxalate supporting solution.
2. Zone electrophoretic behavior of p-BPA was studied by using aqueous ethylene glycol containing sodium chloride. Anionic movement of p-BPA was not observed in any supporting solution. The electric current dropped sharply with decreasing concentration of sodium chloride in solutions.
3. p-BPA did not migrate to the anion side in acotinic or trimesic acid supporting solution. The complexation of p-BPA was found in isocitric or citric acid supporting solution.
4. The stability of complexes of p-BPA against the pH-values of supporting solution was studied by the electrophoresis.
5. Effect of the various supports (pure cellulose paper, acetate paper, phosphate paper) on migration of p-BPA was investigated.

  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] Y.Kitaoka: "Electrophoretic behavior of dihydroxyborylphenylalanine analog in di- and tricarboxylic acid supporting solution"KURRI Prog.Rep.1996. 129-129 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Kitaoka: "Zone electrophoretic behavior of p-dihydroxyborylphenylalanine and electric current in aqueous ethylene glycol containing sodium chloride"KURRI Prog.Rep.1997. 148-148 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Kitaoka: "Electrophoretic behavior of p-dihydroxyborylphenylalanine in tricaboxylic acid supporting solution"KURRI Prog.Rep.1997. 149-149 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Kitaoka: "The complexation of p-boronophenylalanine with ols and carboxylic acids studied by zone electrophoresis"Abstracts of 8th Intl.Symp.on BNCT. 84-84 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Kitaoka: "Specific isolation of p-dihydroxyborylphenylalanine by a zone electrophoresis using a carboxylic acid as a supporting solution"KURRI Prog.Rep.1998. 157-157 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Kitaoka: "Stability of the complex of p-dihydroxyborylphenylalanine against the pH-values of supporting solutions studied by a zone electrophoresis"KURRI Prog.Rep.1998. 158-158 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Kitaoka: "Discussion on the complexation of p-dihydroxyborylphenylalanine with pinacol studied by a zone electrophoresis"KURRI Prog.Rep.1998. 159-159 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Kitaoka: "Effects of various supports on the electrophoretic behavior of dihydroxyborylphenylalanine and picric acid"KURRI Prog.Rep.1998. 160-160 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Kitaoka: "Interaction of dihydroxyborylamino acids with ols or carboxylic acids studied by zone electrophoresis and application of the interaction to isolation of the amino acid"Amino Acids,. 17. 63-63 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y. Kitaoka and M. Kobayashi: "Electrophoretic behavior of dihydroxyborylphenylalanine analog in di-and tricarboxylic acid supporting solution."KURRI Prog. Rep. 1996. 129-129 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Kitaoka: "Zone electrophoretic behavior of p-dihydroxyboryl-phenylalanine and electric current in aqueous ethylene glycol containing sodium chloride."KURRI Prog. Rep. 1997. 148-148 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Kitaoka: "Electrophoretic behavior of p-dihydroxyboryl phenylalanine in tricaboxylic acid supporting solution."KURRI Prog. Rep. 1997. 149-149 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Kitaoka and M. Kobayashi: "The complexation of p-borono-phenylalanine with ols and carboxylic acids studied by zone electrophoresis."Abstracts of 8th Intl. Symp. on BNCT. 84-84 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Kitaoka: "Specific isolation of p-dihydroxyborylphenylalanine by a zone electrophoresis using a carboxylic acid as a supporting solution."KURRI Prog. Rep. 1998. 157-157 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Kitaoka: "Stability of the complex of p-dihydroxyborylphenylalanine against the pH-values of supporting solutions studied by a zone electrophoresis."KURRI Prog. Rep. 1998. 158-158 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Kitaoka: "Discussion on the complexation of p-dihydroxyborylphenylalanine with pinacol studied by a zone electrophoresis."KURRI Prog. Rep. 1998. 159-159 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Kitaoka: "Effects of various supports on the electrophoretic behavior of dihydroxyborylphenylalanine and picric acid."KURRI Prog. Rep. 1998. 160-160 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Kitaoka and M. Kobayashi: "Interaction of dihydroxyborylamino acids with ols or carboxylic acids studied by zone electrophoresis and application of the interaction to isolation of the amino acid."Amino Acids. 17. 63-63 (1999)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2001-10-23  

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