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1999 Fiscal Year Final Research Report Summary

Theoretical studies on mechanism of maintenance of genetic variation at the DNA level

Research Project

Project/Area Number 09640734
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 遺伝
Research InstitutionThe University of Tokyo

Principal Investigator

TAJIMA Fumio  University of Tokyo, Graduate School of Science, Department of Biological Sciences,, 大学院・理学系研究科, 教授 (30183065)

Project Period (FY) 1997 – 1999
Keywordspopulation genetics / DNA polymorphism / natural selection / neutral theory / population structure
Research Abstract

Natural populations have a large amount of genetic variation at the DNA level. How much and why such genetic variation is maintained in a population is one of the most important questions in population genetics. In this research project, I have worked on this subject and obtained the following results.
In order to understand the mechanism of maintenance of DNA polymorphism, we have to measure the amount of DNA polymorphism accurately. There are several statistical methods for estimating the amount of DNA polymorphism. Many of them, however, cannot be used when selective constraints are different among different sites. In this research project, I have developed a new statistical methods for estimating the amount of DNA polymorphism, which can be used even when selective constraints are different among different sites. I have also obtained a new statistical methods for estimating the amount of DNA polymorphism from AFLP data.
When a natural selection is operating on a particular site, we cannot use the neutral theory. I have works on the effect of natural selection on the amount and pattern of DNA polymorphism. One of interesting results is that even when a natural selection is operating on a particular site, we can still estimate the amount of DNA polymorphism in terms of 4Nv, where N is the effective population size and v is the mutation rate. Furthermore, we can estimate the ancestral DNA sequence of the DNA sequences sampled from a population. I have also studied the effect of population structure on the amount of DNA polymorphism.

  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] Innan, H.: "The amounts of nucleotide variation within and between allelic classes and the reconstruction of the common ancestral sequence in a population"Genetics. 147. 1431-1444 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Misawa, K.: "Estimation of the amount of DNA polymorphism when the neutral mutation rate varies among sites"Genetics. 147. 1959-1964 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tajima, F.: "The amount and pattern of DNA polymorphism under the neutral mutation hypothesis"Genetica. 102/103. 103-107 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Innan, H.: "The effect of selection on the amounts of nucleotide variation within and between allelic classes"Genetical Research. 73. 15-28 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Innan, H.: "A method for estimating nucleotide diversity from AFLP data"Genetics. 151. 1157-1164 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Noguchi, Y.: "The mitochondrial genome of the brachipod Laqueus rubellus"Genetics. (印刷中). (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Donnelly, P.: "Progress in Population Genetics and Human Evolution"Springer-Verlag, New York. 329 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Woodruff, R.C.: "Mutation and Evolution"Kluwer Academic Publishers, Netherlands. 580 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Innan, H. and F. Tajima: "The amounts of nucleotide variation within and between allelic classes and the reconstruction of the common ancestral sequence in a population."Genetics. 147. 1431-1444 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Misawa, K. and F. Tajima: "Estimation of the amount of DNA polymorphism when the neutral mutation rate varies among sites."Genetics. 147. 1959-1964 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tajima. F., K. Misawa and H. Innan: "The amount and pattern of DNA polymorphism under the neutral mutation hypothesis"Genetica. 102/103. 103-107 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Innan, H. and F. Tajima: "The effect of selection on the amounts of nucleotide variation within and between allelic classes."Genet. Res.. 73. 15-28 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Innan, H., R. Terauchi, G. Kahl and F. Tajima: "A method for estimating nucleotide diversity from AFLP data."Genetics. 151. 1157-1164 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Noguchi, Y., K. Endo, F. Tajima and R. Ueshima: "The mitochondrial genome of the brachiopod Laqueus rubellus."Genetics. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tajima, F.: "Estimation of the amount of DNA polymorphism and statistical tests of the neutral mutation hypothesis based on DNA polymorphism"Progress in Population Genetics and Human Evolution, edited by P. Donnelly and S. Tavare. Springer-Verlag, New York.. 149-164 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tajima, F., K. Misawa and H. Innan: "The amount and pattern of DNA polymorphism under the neutral mutation hypothesis"Mutation and Evolution, edited by R. C. Woodruff and J. N. Thompson, Jr Kluwer Academic Publishers, Dordrecht Netherlands.. 103-107 (1998)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2001-10-23  

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