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2000 Fiscal Year Final Research Report Summary

Novel anti-adhesive and anti-metastatic activities of trityl-group-containing sugars

Research Project

Project/Area Number 09660079
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 応用微生物学・応用生物化学
Research InstitutionMie University

Principal Investigator

KASHIMURA Naoki  Mie University, Faculty of Bioresources, Professor, 生物資源学部, 教授 (20026412)

Co-Investigator(Kenkyū-buntansha) INAGAKI Minoru  Mie University, Faculty of Bioresources, Assistant Professor, 生物資源学部, 助手 (20242935)
NISHIKAWA Shiro  Mie University, Faculty of Bioresources, Associate Professor, 生物資源学部, 助教授 (50024592)
Project Period (FY) 1997 – 2000
Keywordslipophilic sugars, / antimetstatic activities, / human cancer cell lines, / antiadhesive action, / trityl sugars, / trityl nucleosides, / trityl glycosides, / adhesion molecule
Research Abstract

This project aimed to focus on the anti-invasive and anti-metastatic action of trityl group-containing sugar derivatives, to make molecular design, and to find out novel lead compounds for new anti-cancer drugs, based on the previous studies on the anti-adhesive sugar derivatives. Of more than 500 compounds investigated, 5 derivatives were finally selected to subject to a series of in vitro and in vivo tests. 5'-Trityl uibonucleosides and two tritylcyclodextrin derivatives found to be most effective cadidate for new lead compounds, because of their easy availability of both various isomers and materials, nontoxicity, and effective action in in vivo tests. Especially antiimetastatic cyclodextrins are of interest for future development. Various trityl purine and pyrimidine derivatives were studied on their anti-tumor activities. Several of them were found to be effective in growth inhibition of human cancer cell lines at the concentration of less than 10^<-6>M.One of them was found to be effective in vivo. The main features of the present study include novel biological activity of trityl group in sugars, expected new mechanism, and low toxicity..

  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] 柏村直樹: "糖およびプリン誘導体のスクリーニング成績"癌と化学療法. 25. 266-266 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 柏村直樹: "糖およびプリン誘導体のスクリーニング成績"癌と化学療法. 27. 78-78 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 柏村直樹: "糖質を素材とし新規な作用機構を有する制がん剤の開発"生物資源を活用する新規な制がん剤の研究. 11-17 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 柏村直樹: "生物資源を活用する新規な制がん剤の研究"三重大学地域共同研究センター研究報告書. 8. 144-150 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.Kashimura: "The results of anti-cancer screening tests"Japanese J.Cancer Chemotherapy. 25. 266 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Kashimura: "The results of anti-cancer screening tests"Japanese J.Cancer Chemotherapy. 27. 78 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Kashimura: "Studies on novel lipophilic anti-cancer sugars derived from bioresources, and survey on endocrine disrupters in Mie Prefecture"Research Report, Mie Cooperative Research Center. 11-17 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Kashimura: "Studies on novel lipophilic anti-cancer sugars derived from bioresources, and survey on endocrine disrupters in Mie Prefecture"Research Report, Mie Cooperative Research Center. 8. 144-150 (2000)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2002-03-26  

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