1998 Fiscal Year Final Research Report Summary
Screening of New Biocatalysts and Its Application to the Synthesis of Biologically Active Compounds
| Project/Area Number |
09660120
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Bioproduction chemistry/Bioorganic chemistry
|
|---|
| Research Institution | Depatment of Chemistry, Keio University |
|---|
Principal Investigator |
SUGAI Takeshi Keio University, Dept.of Chemistry Associate Professor, 理工学部, 助教授 (60171120)
|
|---|
| Project Period (FY) |
1997 – 1998
|
| Keywords | Amino Alcohol / Ceramide / Lipase / Kinetic Resolution / Pheromone / Amino Sugar / Regioselective Acylation |
|---|
| Research Abstract |
Results of screeing of new biocatalysts and its application to the synthesis of biologically active compounds are summalized as follows. 1) pivotal role of (E)-3-carbamoyl-1-propenylboronic acid in the combination of Suzuki-Miyaura coupling and enzyme reactions : synthesis of (3E,5E)- and (3E,5Z)-6-phenyl-3,5-hexadienoic Acid ; 2) biocatalyst-mediated efficient preparation of highly enantiomerically enriched (R)-5-hexanolide ; 3) A chemo-enzymatic synthesis of D-allosamine derivatives from Tri-O-acetyl-D-glucal ; 4) Rhodococcus rhodochrous IFO 15564-mediated hydrolysis of alicyclic nitriles and amides : its stereoselectivity, and the use for kinetic resolution and asymmetrization ; 5) lipase-catalyzed enantiomeric resolution of ceramides.
|
Research Products
(12 results)
