1998 Fiscal Year Final Research Report Summary
The participation of apoptosis in the suppression of the proliferation of human leulemia cells by the plant constituent
| Project/Area Number |
09660135
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
食品科学・栄養科学
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| Research Institution | MIE UNIVERSITY |
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Principal Investigator |
KOMIYA Takashi Mie University Faculty of Bioresources Professor, 生物資源学部, 教授 (60024577)
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| Co-Investigator(Kenkyū-buntansha) |
UMEKAWA Hayato Mie University Faculty of Bioresources Associater Professor, 生物資源学部, 助教授 (90185059)
HIBASAMI Hiroshige Mie University Faculty of Medicine Professor, 医学部, 教授 (60024642)
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| Project Period (FY) |
1997 – 1998
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| Keywords | catechins / theaflavins / honokiol / oleanoic acid / urosolic acid / change of cell molphology / DNA fragmentation / apoptosis |
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| Research Abstract |
Anticanncer drugs used clinically have side effects and tumor cells are resistant to these drugs. Therefore, new type of anticancer drugs are desirable. This study was conducted to find out new compounds having ability of apoptosis, and to determine structure of the compound and its mechanism of antitumor activity. Persimmon extract and its components such as catechins, specially epigallocatechin gallate(EGCG) suppressed the growth of human leukemia. Moreover, green tea extract, EGCG and black tea component, the aflavin also suppressed the proliferation of leukemia cells. By these components morphology of these cells were changed, and apoptotic bodies and DNA fragments were observed. In other experiment, honokiol was isolated from leaves of honoki and investigated the antitumor activity of honokiol. This compound also inhibited the growth of leukemia cells by inducing apoptosis. In the last experiment, oleanoic acid and ursolic acid were isolated from loquat. These compounds inhibited the activity of ornithine decarboxylase but not induce apoptosis in these leukemia cells. These findings suggest the suppression of the growth result from the synthesis of polyamines.
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[Publications] Komiya, T., Y.Achiwa, H.Katsuzaki, K.Imai, S.Sakurai, K.Urakawa, K.Ohnishi, T.Adachi, T.Yamada and H.Hibasami: "Effect of Oleanoic-and Ursolic Acids Isolated from Loquat (Eriobotrya) on the Growth of Human Lymphoid Leukemia cells." Food Sci.Technol., int.4 (4). 282-284 (1998)
Description
「研究成果報告書概要(欧文)」より
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