1999 Fiscal Year Final Research Report Summary
Endothelial Cell-Pericyte Interdigitation in Angiogenesis
| Project/Area Number |
09660332
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Azabu University School of Veterinary Medicine |
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Principal Investigator |
WAKUI Shin Azabu University, 獣医学部, 助教授 (40201157)
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| Project Period (FY) |
1997 – 1999
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| Keywords | Angiogenesis / Endothleial cell-pericyte interdigitation |
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| Research Abstract |
In the present study, I have investigated the ultrastructural localization of TGFb, plasminogen activator(PA) and pasminogen(Pn) in granulation tissue. Angiogenesis is a prominent feature of granulation tissue and is largely composed of an abundance of immature capillaries. A number of endothleial cell-pericyte interdigitation(EPI) are observed in immature capillaries in granulation tissue. In this study, TGFb, PA, and Pn immunoreactivities were colocalized selectively at a large number of the EPI in the newly formed capillaries. The present study opens several new directions for the study concerning angiogenesis in situ, especially the heterotypic cell-to-cell interaction(EPI) with angiogenic process.
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[Publications] Mangold,K., Takahashi,H., Brandigi,C., Wada,T., Wakui,S., Furusato.M., M.Boyd, J.Candler, F.Allsbrook,W.: "P16(CDKN2/MTSI) tumor suppressor deletions are present in prostatic carcinoma in Japanese but not Americans"Journal of Urology. 157. 1117-1120 (1997)
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「研究成果報告書概要(欧文)」より
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[Publications] Wakui,S., Furusato,M., Muto,T., Sasaki,S., Takahashi,H., Ushigome,S.: "Expression of sialic acid in renal tubule in streptozotocin induced diabetes rats."Journal of Toxicologic Pathology. 11. 49-54 (1998)
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[Publications] Takahashi,H., Ichimiya,S., Nimura,Y., Watanabe,M., Furusato,M., Wakui,S., Yatani,R., Aizawa,S., Nakagawa,A.: "Mutation, allelotyping, and transcription analyses of the p73 gene in prostatic carcinoma."Cancer Research. 58. 2076-2077 (1998)
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[Publications] Wakui,S., Furusato,M., Muto,T., Sasaki,S., Takahashi,H., Masaka,T., Ushigome,S.: "Expression of vascular endothelial growth factor in N-butyl-N-(4-hydroxybutyl) nitrosamine induced rat bladder carcinogenesis."Veterinary Pathology. 36. 111-116 (1999)
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[Publications] Muto,T., Wakui,S., Takahashi,H., Maekawa,S., Masaoka,T., Ushigome,S., Furusato,M.: "p53 gene mutation occurring in spontaneous benign and malignant mammary tumors of the dog."Veterinary Pathology. 37 in press. (2000)
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