1998 Fiscal Year Final Research Report Summary
Role of angiotensin II type 2 receptors in the development of stress-induced hyperthermia in mouse : a knockout mouse study
| Project/Area Number |
09670071
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Yamaguchi University |
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Principal Investigator |
WATANABE Tatsuo Yamaguchi University School of Medicine, Associate Professor, 医学部, 助教授 (60182929)
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| Project Period (FY) |
1997 – 1998
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| Keywords | Angiotensin II / Angiotensin receptors / Stress / Knockout mouse / Fever |
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| Research Abstract |
We investigated the effect of angiotensin II type 2 receptor (AT_2)-gene disruption on the hyperthermia induced by immunological [Iinterleukin-1 (IL- 1)-injection] and non-immunological (saline-injection or cage-switch) stress. AT_2-deficient and control mice showed increases in body temperature and physical activity during dark period. AT_2-deficient mice exhibited a lower body temperature than the controls during the dark period. AT_2-deficient mice showed a significantly smaller hyperthermia than the controls after intraperitoneal (i.p.) injection of IL-1beta. By comparison with the controls, AT_2-deficient mice had significantly greater increases in body temperature after i.p. saline or during cage-switch stress. These results suggest that AT_2 plays important roles in stress-induced hyperthermia in mice.
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