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1998 Fiscal Year Final Research Report Summary

Role of angiotensin II type 2 receptors in the development of stress-induced hyperthermia in mouse : a knockout mouse study

Research Project

Project/Area Number 09670071
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionYamaguchi University

Principal Investigator

WATANABE Tatsuo  Yamaguchi University School of Medicine, Associate Professor, 医学部, 助教授 (60182929)

Project Period (FY) 1997 – 1998
KeywordsAngiotensin II / Angiotensin receptors / Stress / Knockout mouse / Fever
Research Abstract

We investigated the effect of angiotensin II type 2 receptor (AT_2)-gene disruption on the hyperthermia induced by immunological [Iinterleukin-1 (IL- 1)-injection] and non-immunological (saline-injection or cage-switch) stress. AT_2-deficient and control mice showed increases in body temperature and physical activity during dark period. AT_2-deficient mice exhibited a lower body temperature than the controls during the dark period. AT_2-deficient mice showed a significantly smaller hyperthermia than the controls after intraperitoneal (i.p.) injection of IL-1beta. By comparison with the controls, AT_2-deficient mice had significantly greater increases in body temperature after i.p. saline or during cage-switch stress. These results suggest that AT_2 plays important roles in stress-induced hyperthermia in mice.

  • Research Products

    (2 results)

All Other

All Publications (2 results)

  • [Publications] Watanabe, T.: "Effects of targeted disruption of the mouse angiotensin II type 2 receptor gene on stress-induced hyperthermia." Journal of Physiology(London). in press.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Watanabe, T.: "Effects of targeted disruption of the mouse angiotensin II type 2 receptor gene on stress-induced hyperthermia." Journal of Physiology (London). (in press).

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-12-08  

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