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2000 Fiscal Year Final Research Report Summary

Evaluation of pharmacodynamics of drugs acting on the central nervous system using computer-assisted eye movement analysis.

Research Project

Project/Area Number 09670105
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General pharmacology
Research InstitutionShowa University

Principal Investigator

UCHIDA Eiji  Showa University, School of Medicine, Associate Professor, 医学部, 助教授 (80175223)

Co-Investigator(Kenkyū-buntansha) KURATA Norimitsu  Showa University, School of Medicine, Assistant Professor., 医学部, 講師 (80231299)
Project Period (FY) 1997 – 2000
Keywordspharmacodynamics / pharmacokinetics / CNS / saccadic peak velocity / smooth eye pursuit / ethnic difference / gender difference / menstrual cycle
Research Abstract

Computer-assisted eye movement analysis (C-EMA) seems to be a useful tool to clarify relationship between pharmacokinetics (PK) and pharmacodynamics (PD) of drugs acting on the central nervous system (CNS). We evaluated PK/PD of nitrazepam, widely used antianxiety, by using C-EMA system. 1. Eight volunteers participated in a double-blinded randomized placebo controlled study in a crossover fashion. Saccadic peak velocity (SPV) was significantly reduced by nitrazepam treatment. No significant effect was observed for smooth pursuit eye movement (SPEM). 2. Gender differences in PK/PD of nitrazepam were studied with 8 female and 8 male volunteers in a placebo controlled double blind crossover trial. SPV significantly decreased in both groups. Basic values of SPEM were significantly lower in a female group. 3. Ethnic difference in PK/PD of nitrazepam was studied with age and gender matched 8 Caucasians and 8 Japanese subjects by C-EMA.No differences were observed for PK/PD of nitrazepam in both ethnic groups. 4. Effect of menstrual cycle on C-EMA was evaluated in 8 female volunteers. SPV and SPEM did not differ during 2 menstrual cycles. We concluded that C-EMA is a useful tool for evaluating drugs acting on the CNS because of its sensitive, simple, and reproducible features.'

  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] 保田国伸 他: "健常日本人におけるコンピュータ眼球運動解析とVisual Analogue Scaleを用いたNitrazepamの薬物動態-薬力学相関に対する評価"臨床薬理. 28. 703-713 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 幸田隆彦 他: "眼球運動解析システム.VASを用いたニトラゼパムの薬理作用に関する性差の検討"臨床薬理. 29. 197-198 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] van Gerven JMA, et al.: "Pharmacodynamics and pharmacokinetics of a single oral dose of nitrazepam in healthy volunteers : An interethnic comparative study between Japanese and European Volunteers"J.Clin Pharmacol. 38. 1129-1136 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 幸田隆彦 他: "眼球運動解析を用いたnitrazepenの薬理作用と薬物動態に関する性差の検討"臨床薬理. 30. 443-455 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 内田英二 他: "日本人および白人を対象としたNitrazapan単回投与後の薬物動態・薬力学の比較"臨床薬理. 31. 247-248 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yasuda K, et al.: "Evaluation of pharmacokinetic-pharmacodynamic relationship of nitrazepam using computerized eye movement analysis and visual analogue scales in healthy Japanese volunteers."JPN J Clin Pharmacol. 28. 703-713 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Koda T, et al.: "Gender differences in pharmacodynamics of nitrazepam using computer-assisted eye movement analysis."JPN J Clin Pharmacol. 29. 197-198 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] JMA van Gerven, et al.: "Pharmacodynamics and pharmacokinetics of a single oral dose of nitrazepam in healthy volunteers : An interethnic comparative study between Japanese and European volunteers."J Clin Pharmacol. 38. 1129-1136 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] KODA T, et al.: "Gender differences in pharmacokinetics and pharmacodynamics of nitrazepam in healthy young Japanese volunteers."JPN J Clin Pharmacol. 30. 443-455 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] UCHIDA E, et al.: "Interethnic comparison of pharmacokinetics and pharmacodynamics of nitarazepam using computer-assisted eye movement analysis."JPN J Clin Pharmacol. 31. 247-248 (2000)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2002-03-26  

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