1998 Fiscal Year Final Research Report Summary
Study on modifying factors in the development of EBV-associated lymphomas
| Project/Area Number |
09670184
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Osaka University |
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Principal Investigator |
AOZASA Katsuyuki Osaka University Medical School, Professor, 医学部, 教授 (30115985)
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| Co-Investigator(Kenkyū-buntansha) |
KANNO Hiroyuki Osaka University Medical School, Associate Professor, 医学部, 助教授 (40252663)
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| Project Period (FY) |
1997 – 1998
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| Keywords | EBV / nasal lymphoma / pyothorax-associated lymphoma / CTL / EBNA4 |
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| Research Abstract |
Nasal lymphoma(NL) and pyothorax-associated lymphoma(PAL) were the subjects in 1998.Results of the study on NL were as follows : (1) frequency of NL in the recent 10 years decreased to about 50% of the previous 15 years in Korea but slight decrease in Japan ; (2) combined immunophenotypic and genotypic studies showed that NL of lethal midline granuloma type is a neoplasia of natural killer(NK) cell.To elucidate the escape mechanism of EBV latent gene expressing PAL cells from host immune surveillance, CTL epitope of EBNA 4 regions was sequenced.The results showed mutations of the CTL epitope in 5 of 6 PAL cases examined, suggesting the mutations of EBV antigens contributed to development of PAL.
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