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1998 Fiscal Year Final Research Report Summary

Mechanisms of constrictive remodeling at the site of restenosis after PTCA

Research Project

Project/Area Number 09670198
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionOSAKA CITY UNIVERSITY

Principal Investigator

UEDA Makiko  OSAKA CITY UNIVERSITY MEDICAL SCHOOL,PROFESSOR, 医学部, 教授 (10137193)

Project Period (FY) 1997 – 1998
KeywordsRestenosis / Constrictive remodeling / Vasoactive substance / PTCA / Coronary artery
Research Abstract

Restenosis after an initial successful percutaneous transluminal coronary angioplasty (PTCA) remains a signifiant clinical problem. The mechanisms that underlie restenosis are still unclear. Initial reports have documented a proliferative cellular response as the main pathological feature. More recently, so-called late remodeling has been introduced as a mechanism, although the processes causing this phenonenon are unclear still.
The present study demonstrates that, during neointimal formation at the site of PTCA, smooth muscle cells show phenotypic changes, indicated by altered expression of smooth muscle myosin heavy chain (Circulation 96 : 82-90, 1997). The present study, moreover, documents that up-regulation of angiotensin converting enzyme and endothelin converting enzyme occurs during neointimal formation after PTCA, especially at the early stage of neointimal formation. (Circulation 96 : 3328-3337, 1997 ; J.Hypertens, 15 : 1295-1302 ; Circulation 96 : I-348, 1997). Furthermore, The present study reveals that the expression of endothelin type A receptor is also up-regulated in neointimal smooth muscle cells at the site of PTCA (Circularion 98 : I-734, 1998)

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] Aikawa M,Sakomura Y,Ueda M,etal.: "Redifferentiation of smooth muscle cells after coronary angioplasty determined ia myosin heavy chain expression." Circulation. 96. 82-90 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ohishi M,Ueda M,et al.: "Upregulation of angiotensin-converting enzyme during the healing process after injury at the site of percutaneous transluminal coronary angioplasty in humans." Circulation. 96. 3328-3337 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Naruko T,Ueda M,et al.: "Endothelin and endothelin-converting enzyme expression at the site of percutaneous transluminal coronary angioplasty in humans." Circulation. 96. I-348 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ohishi M,Ueda M,et al.: "Enhanced expression of angiotensin-converting enzyme is associated with progression of coronary atherosclerosis in humans." J.Hypertens,. 15. 1295-1302 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Komatsu R,Ueda M et al.: "Neointimal tissue response at sites of coronary stenting in humans." Circulation. 98. 224-233 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Naruko T,Ueda M,et al.: "Increased Expression of Endothelin Receptors is Associated with the Progression of Atherosclerosis in Human Coronary." Circulation. I-734 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小松龍士,上田真喜子: "心臓病診療プラクティス18・インターベンションを活かす「再狭窄の機序」" 文光堂, 6 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 笠行典章,上田真喜子: "心臓病診療プラクティス17・血管疾患を診る「動脈硬化の最近の病因論」" 文光堂, 3 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Akikawa M, Sakomura Y, Ueda M, et al.: "Redifferentiation of smooth muscle cells after coronary angioplasty determined via myosin heavy chain expression." Circulation. 96. 82-90 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohishi M, Ueda M, et al.: "Upregulation of angiotensin-converting enzyme during the healing process after injury at the site of percutaneous transluminal coronary angioplasty in humans." Circulation. 96. 3328-3337 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Naruko T, Ueda M, et al.: "Endothelin and endothelin-converting enzyme expression at the site of percutaneous transluminal coronary angioplasty in humans." Circulation. 96. I-348 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohishi M, Ueda M, et al.: "Enhanced expression of angiotensin-converting enzyme is associated with progression of coronary atherosclerosis in humans." J.Hypertens. 15. 1295-1302 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Komatsu R, Ueda M et al.: "Neointimal tissue response at sites of coronary stenting in humans." Circulation. 98. 224-233 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Naruko T, Ueda M, et al.: "Increased expression of endothelin receptors is Associated with the progression of Atherosclerosis in human coronary arieries." Circulation. 98. I-734 (1998)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-12-08  

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