1998 Fiscal Year Final Research Report Summary
Intracellular localization of multidrug resistance associated protein (MRP) and atypical multidrug resistance phenomenon in non-small cell lung cancer
| Project/Area Number |
09670205
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Tokai University |
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Principal Investigator |
NAKAMURA Masato Tokai University School of Medicine Assistant Professorr, 医学部, 講師 (00164335)
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| Co-Investigator(Kenkyū-buntansha) |
KIJIMA Hiroshi Tokai University School of Medicine Assistant Professor, 医学部, 講師 (90204859)
YAMAZAKI Hitoshi Tokai University School of Medicine Assistant Professor, 医学部, 講師 (20191273)
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| Project Period (FY) |
1997 – 1998
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| Keywords | lung cancer / multidrug resistance / MRP gene / molecular pathology |
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| Research Abstract |
Multidrug resistance-associated protein (MRP) is one of the major factors for non-P-glycoprotein (PGp)-mediated multidrug-resistance. It is unclear how MRP expression is regulated in NSCLC.In this study, we examined MRP and mutant p53 expression in 107 NSCLC by immunohistochemical procedures. Forty-seven of these 107 NSCLC cases were positive for MRP in the cytoplasm. Mutant p53-positive NSCLC showed a significant correlation with MRP overexpression. Coexpression of MRP and p53 in the same cells of NSCLC was confirmed by double staining procedures. Twenty-six patients with MRP-positive tumors who underwent postoperative chemotherapy with MRP-related anticancer drugs showed significantly poorer prognosis than those with MRP-negative tumors. This correlation between MRP expression and prognosis was also seen in stage Ill patients, and in patients with squamous cell carcinoma. NSCLC patients with coexpression of MRP and p53 showed poorer prognosis than those without MRP and p53. These results suggest that MRP overexpression affected by mutant p53 has a significant effect on prognosis through atypical non-PGp-mediated multidrug resistance in NSCLC.
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[Publications] Yoshiyuki Abe, Yoshiro Oshika, Yasuyuki Ohnishi, Ryuji Suto, Tetsuji Tokunaga, Hitoshi Yamazaki, Hiroshi Kijima, Nobuyoshi Hiraoka, Yoshito Ueyama, Norikazu Tamaoki, Masato Nakamura: ""A xenograft line of human teratocarcinoma established by serial transplantation in severe combined immunodeficient (SCID) mice"" APMIS. 105. 283-289 (1997)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Ryuji Suto, Yoshiyuki Abe, MasatoNakamura, Yasuyuki Onishi, Masumi Yoshimura, Yoon Hwan Lee, Takashi Imanishi, Hitoshi Yamazaki, Hiroshi Kijima, Testuji Tokunaga, Yoshiro Oshika, Nobuyoshi Hiraoka, Norikazu Tamaoki, Hiroaki Fukuda, Yoshito Ueyama: ""Multidrug resistance mediated by overexpression of P-glycoprotein in human osteosarcoma in vivo"" Intl J Onc. 12. 287-291 (1998)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Tetsuji Tokunaga, Yoshiro Oshika, Yoshiyuki Abe, Yuichi Ozeki, Sotaro Sadahiro, Hiroshi Kijima, Takashi Tsuchida, Hitoshi Yamazaki, Yoshito Ueyama, Norikazu Tamaoki, Masato Nakamura: "Vascular endothelial growth factor (VFGF) mRNA isoform expression pattern is correlated with liver metastasisand poor prognosis in colon cancer." BrJ Cancer. 77. 998-1002 (1998)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Yoshitaka Fukushima, Yoshiro Oshika, Tetsuji Tokunaga, Hiroyuki Hatanaka, Masashi Tomisawa, Kenji Kawai, Yuichi Ozeki, Takashi Tsuchida, Hiroshi Kijima, Hitoshi Yamazaki, Yoshito Ueyama, Norikazu Tamaoki, Masato Nakamura.: "Multidrug resistance-associatedprotein (MRP) expression is correlated with aberration of p53 protein in colorectal cancer." Eur J Cancer. (in press). (1999)
Description
「研究成果報告書概要(欧文)」より
