1999 Fiscal Year Final Research Report Summary
Molecular Pathology of Glycosyltransferases Involved in the Progression of Colorectal Cancer
| Project/Area Number |
09670222
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Shinshu University |
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Principal Investigator |
NAKAYAMA Jun University Hospital, Shinshu University, Assistant Professor, 医学部・附属病院, 講師 (10221459)
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| Co-Investigator(Kenkyū-buntansha) |
KATSUYAMA Tsutomu School of Medicine, Shinshu University, Professor, 医学部, 教授 (90020809)
AKAMATSU Taiji University Hospital, Shinshu University, Associate Professor, 医学部・附属病院, 助教授 (80212413)
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| Project Period (FY) |
1997 – 1999
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| Keywords | colorectal cancer / glycosyltransferase / molecular pathology |
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| Research Abstract |
Neoplastic transformation of epithelial cells is accompanied by alterations of the cell-surface carbohydrates, and many of them can be detected by specific antibodies, thus providing tumor-associated antigens. Recently, it was shown that sialyl Lewis X expressed on the colorectal cancer cells is positively correlated with the poor prognosis of the patients.
In this project, we have investigated the clinicopathological significance of two particular glycosyltransreareases, core 2 β1,6-N-acetylglucosaminyltransfearase (C2GnT) and β1,4-galactosyltransferase-l (β4GalT-l) in the colorectal tumors. C2GnT is a key enzyme of the O-glycan biosynthesis, and β4GalT-l is a key enzyme for the biosynthesis of N-acetyllactosamine attached to N-glycans. As results, we have shown that the expression level of β4Gall-l was significantly enhanced during the progression of colorectal adenoma to cancer. In addition, it was also demonstrated that the expression of C2GnT in colorectal cancers was positively correlated with the vessel invasion and depth of invasion of the cancer cells. These results altogether strongly suggest that these glycosyltransferases play important roles for the pathogenesis and progression of colorectal cancer.
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[Publications] Ichikawa T, Nakayama J, Sakura N, Hashimoto T, Fukuda M, Fukuda MN, Taki T,: "Expression of N-acetyllactosamine and β1,4-galactosyl-transferase, β4GalT-1, during adenoma-carcinoma sequence in the human colorectum."J. Histochem. Cytochem.. 47. 1593-1601 (1999)
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