2000 Fiscal Year Final Research Report Summary
Epidemiological and molecular biological study of familial factors in occurrence of children's leukemia
| Project/Area Number |
09670380
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Kyorin University (2000)
The University of Tokyo (1997-1999) |
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Principal Investigator |
BESSHO Fumio Kyorin University, Department of Pediatrics, Professor, 医学部, 教授 (40010285)
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| Co-Investigator(Kenkyū-buntansha) |
TANIMURA Masako National Children's Medical Research Center, Department of Child Ecology, Director, 小児医療研究センター・小児生体研究部, 部長 (90014191)
KOBAYASHI Miyuki University of Tokyo Hospital, Department of Pediatrics, Assistant Professor, 医学部・附属病院, 講師 (60205391)
HAYASHI Yasuhide University of Tokyo Hospital, Department of Pediatrics, Assistant Professor, 医学部・附属病院, 講師 (30238133)
YOSHINO Hiroshi Kyorin University, Department of Pediatrics, Assistant, 医学部, 助手
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| Project Period (FY) |
1997 – 2000
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| Keywords | Pediatric cancer / Familial occurrence / Tumor suppressor genes / Etiological factors / Familial leukemia / Familial cancer |
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| Research Abstract |
Objectives : Several evidences showed that some of children's leukemia have their origin in utero and they develop into overt leukemia after one or more additional genetic events. If frequency of mutation is proportional to frequency of DNA replication, active cell division of spermatogonia to produce sperm can accumulate such mutation much more in older male than young male and as the result father of children with leukemia might be older than father of children without cancers. Methods : Data of ages of parents at the time of birth of children with acute lymphocytic leukemia (ALL), acute myelogenous leukemia (AML), neuroblastoma or hepatoblastoma were provided by the Children's Cancer Registry of Japan. Data of parents of children who visited 5 hospitals for acute illness were served as control. Results : Distribution curves of ages of parents of children with ALL diagnosed at the ages between 2 to 6 years were completely overlapped. Mean ages with SD of father and mother of children with ALL were 383.5 +/- 67.1 months and 348.9 +/- 53.3, respectively. Those of controls were 382.6 +/- 65.3 and 349.4 +/- 54.6, respectively. The results for the children with ALL of other age ranges, AML and embryonal tumors (neuroblastoma, Wilms tumor, hepatoblastoma) were similar. Conclusion : There were no significant differences between ages of either fathers or mothers of children with cancers examined. Hypothesis that older parents might have accumulated carcinogenic mutations in their sperm or ovum was not substantiated.
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[Publications] I.Kong X-T, Choi SH, Inouc A, Chen T, Takita J, Yokota J, Bessho F, Yanagisawa M, Hanada R, Yamamoto K, Hayashi Y: "Expression and mutational analysis of the DCC,DPC4 and MADR2 genes in ncuroblastoma"Cancer Research. 57. 3772-3778 (1997)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Ohnishi H.Guo SX, Ida K, Taki T, Naritaka S, Bessho F, Yanagisawa M, Hanada R, Eguchi M, Kamada N, Kita K, Yamamori S, Hayashi Y: "Alteration of p16 and p15 genes in acute leukemia with MLL gene rearrangements and their correlation with clinical features."Leukemia. 11. 2120-2124 (1997)
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「研究成果報告書概要(欧文)」より
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[Publications] Kawamura M, Ohnishi H, Guo S-X, Sheng XM, Minegishi M, Hanada R, Horibe K, Hongo T, Kaneko Y, Bessho F, Yanagisawa M, Sekiya T, Hayashi Y: "Aleterations of the p53, p21, p16, p15 and RAS genes in childhood T-cell acute lymphoblastic leukemia."Leukemia Res. 23. 115-126 (1999)
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「研究成果報告書概要(欧文)」より
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[Publications] Yang HW, Piao HY, Chen YZ, Takita J, Kobayashi M, Taniwaki M, Hashizume K, Hanada R, Yamamoto K, Taki Tomohiko, Bessho F, Yanagiasawa M, Hayashi Y: "The p73 gene is less involved in the development but involved in the progression of neuroblastoma."Intern J Mol Med. 5. 379-384 (2000)
Description
「研究成果報告書概要(欧文)」より
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