1998 Fiscal Year Final Research Report Summary

The association of polymorphisms of tyrosine kinases with atopic diseases

Research Project

Project/Area Number	09670472
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	内科学一般
Research Institution	The University of Tokyo
Principal Investigator	MORITA Yutaka The University of Tokyo, Hospital Intemal Medicine, Associate Professor, 医学部・附属病院, 助教授 (60107620)
Co-Investigator(Kenkyū-buntansha)	HONDA Zenichiro The University of Tokyo, Hospital Intemal Medicine, Lecturer, 医学部・附属病院, 講師 (70238814) KIHARA Hidetoshi Kihara Clinic Director, 院長 KITANI Seiichi The University of Tokyo, Assistant Professor, 保健センター, 助手 (10231284)
Project Period (FY)	1997 – 1998
Keywords	Syk / bronchial asthma / polymorphisms
Research Abstract	Abstract Bronchial asthma is initiated with the inflammatory reactions of mast cells, lymphocytes and eosinophils caused by allergen. Syk is activated in inflammatory cells such as Blymphocytes, platelets, mast cells, monocytes, macrophages, T-cells and granulocytes. We studied the mutation of human syk molecule through association approach as analysis of genetic factor of asthma. There was the positive association between DNA sequence variant at 1449G/C, 1485G/A, 1668C/T and 1692T/C in kinase domain in syk gene and asthma phenotype trait (p<0.01). This polymorhisms could lead toward the disease-specific gene near syk locus with further genetic linkage analysis.

(2 results)