1999 Fiscal Year Final Research Report Summary
Matrix metalloproteinases in chronic liver diseases and hepatocellular carcinoma.
| Project/Area Number |
09670550
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Tottori University |
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Principal Investigator |
MURAWAKI Yoshikazu Tottori University Hospital, 2nd Dept Intern Med, Assistant professor, 医学部附属病院, 講師 (90144659)
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| Project Period (FY) |
1997 – 1999
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| Keywords | MMP-1 / MMP-2 / MMP-3 / MMP-9 / LIVER DISEASE |
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| Research Abstract |
To elucidate the clinical usefulness of serum matrix metalloproteinase (MMP)-1, MMP-2, MMP-3 and MMP-9 in chronic liver disease and hepatocellular carcinoma, we measured these enzyme concentrations in serum and liver, and compared the results with clinicopathological findings.
(1)Serum MMP-1 concentration decreased during histological progression of chronic hepatitis. The serum MMP-1 test was useful clinically to differentiate active and inactive types of hepatitis in patients with chronic viral hepatitis.
(2)The serum MMP-2 concentration refects mainly the amount of proMMP-2 complexed with TIMP-2. The serum MMP-2 level was markedly increased in cirrhotic patients, and may be explained by an overproduction in the cirrhotic liver. In the clinical state, the measurement of serum MMP-2 was as useful a test for diagnosing liver cirrhosis as the serum hyaluronan test.
(3)The plasma MMP-9 level, as well as the MMP-2 level, was significantly increased in cirrhotic patients, probably due to overproduction in the cirrhotic liver. However, the plasma MMP-9 test was inferior to the plasma MMP-2 test for the diagnosis of cirrhosis.
(4)The serum MMP-3 concentration was about 2-fold higher in the males than in the females, and 55% lower in chronic hepatitis, 53% lower in liver cirrhosis and 46% lower in hepatocellular carcinoma. The MMP-3 concentration in the cirrhotic liver was quite similar to that in the non-cirrhotic liver. The measurement of serum MMP-3 was of little use for assessing fibrolysis in chronically diseased livers.
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