1998 Fiscal Year Final Research Report Summary
Control of interstitial pneumonia by reducing nitric oxide production
| Project/Area Number |
09670607
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
SHIMOKATA Kaoru School of Medicine, Nagoya University Professor, 医学部, 教授 (10022906)
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| Co-Investigator(Kenkyū-buntansha) |
HASEGAWA Yoshinori School of Medicine, Research Associate, 医学部, 助手 (20270986)
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| Project Period (FY) |
1997 – 1998
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| Keywords | nitric oxide / interstitial pneumonia / radiation |
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| Research Abstract |
Radiation pneumonitis is a major complication of radiation therapy. To elucidate the mechanisms of radiation-induced pneumonitis, we studied nitric oxide (NO) produced from lung tissues using a model of unilaterally irradiated rats. Our results demonstrated that alveolar macrophages (AM) produced NO after irradiation, and the expression of inducible NO synthase (NOS) in both AM and alveolar epithelial cells was increased. Furthermore, the progression of radiation pneumonitis was reduced with the in vivo treatment of the NOS inhibitor N^G-nitro-L-arginine methyl ester (L-NAME). The effect of L-NAME was further confirmed by the inhibition of mRNA expression for procollagen-alpha_1 type III of the lung. With these results, NO produced from AM and alveolar epithelial cells after irradiation may be an important mediator in the progression of radiation pneumonitis.
We measured CO concentration in expired air of healthy subjects. Reproducibility of the data was satisfactory and estimation of CO concentration in expired air was considered to be applicable in clinical situation.
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Research Products
(2 results)
