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1998 Fiscal Year Final Research Report Summary

Gene therapy for lung cancer using tumor suppressor gene product as molecular target

Research Project

Project/Area Number 09670615
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionUniversity of Tokushima

Principal Investigator

SHIMIZU Eiji  University of Tokushima, School of Medicine, Lecturer, 医学部, 講師 (50187449)

Co-Investigator(Kenkyū-buntansha) KAWANISHI Masashi  University of Tokushima, School of Medicine, Asistant, 医学部, 助手 (90301316)
Project Period (FY) 1997 – 1998
KeywordsLung cancer / Oncogene / Tumor suppressor gene / p16, rb / Gene therapy / Chemotherapy / Pleuritis carcinomatosa / Cisplatin
Research Abstract

Treatment of inoperable lung cancer with pericarditis carcinomatosa consists of pleural administration of anticancer agents and/or inflammation-inducing agents, which have not improved the survival of the patients significantly because of poor local control and distant metastasis. Gene therapy for lung cancer using tumor suppressor gene including p53, rb, p16, an alternative of chemoimmunotherapy, which has recently developed in lung cancer, may improve the survival of the inoperable lung cancer patients with pleuritis carcinomatosa. In this study, we examined the basic and preclinical evaluation of rb and p16 in patients with carcinomatous pleural effusion. Under written informed consent, mononuclear cells were isolated from pleural effusion with seven patients with T4 status. Characteristics of patients include five males and two females/median age 72/6 adenocarcinomas and one small cell carcinoma. These samples formed 0-120 colonies per 200,000 mononuclear cells and five of seven patients were evaluable for antitumor

  • Research Products

    (26 results)

All Other

All Publications (26 results)

  • [Publications] Takeuchi E,et al: "A case of pleomorphic adenoma of the lung with multiple distant metastases-observations on its oncogene and tumor suppressor gene expression." Anticancer Res. 18. 2015-2020 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ise Y,et al: "An autopsy case of cytokeratin 7-positive minute adenocarcinoma of the lung with systemic metastases." Intern Med. 37. 766-769 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoshida S,et al: "Synchronous small cell carcinoma and adenocarcinoma of the lung representing different retinoblastoma tumor suppressor protein status." Int J Clin Oncol. 3. 326-329 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Moriguchi S,et al: "Exercise training restores the decreased cellular immune function in obese Zucker rats via improvement of GLUT-1 expression." J Appl Physiol. 84. 311-317 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Moriguchi S,et al: "Decreased mitogen response of splenic lymphocytes in obese Zucker rats is associated with the decreased expression of glucose transporter-1 (GLUT-1)." Am J Clin Nutr. 67. 1124-1129 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Houchi H et al: "Endothelin-1 stimulates sodium-dependent calcium efflux from bovine adrenal chromaffin cells in culture." Br J Pharmacol. 125. 55-60 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hirose M,et al: "Expression level of Gl-cyclins and cell proliferation in human cultured leukemia/lymphoma cell lines." Int J Oncol. 12. 841-846 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kondo K,et al: "High frequency expressions of CD44 standard and variant forms in non-small cell lung cancers,but not in small cell lung cancers." J Surg Oncol. 69. 128-136 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamamoto A,et al: "Infrequent presence of anti-c-Myc antibodies and absence of c-Myc oncoprotein in sera from lung cancer patients." Oncology. 56. 129-133 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Namikawa O,et al: "Analysis of antibodies to p16INK4A tumor suppressor gene products in lung cancer patients." Int J Oncol. in press. (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoshimoto K,et al: "Infrequent detectable somatic mutations of the RET and glial cell line-derived neurotrophic factor (GDNF) genes in human pituitary adenomas." Endocrine J. in press. (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 清水英治他: "内科学書、島田 馨編" 中山書店, 4 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 清水英治他: "内科学書、島田 馨編" 中山書店, 5 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takeuchi E, Shimizu E, Sano N, Yamaguchi T, Yanagawa H and Sone S: "A case of Pleomorphic adenoma of the lung with multiple distant metastases-observations on its oncogene and tumor suppressor gene expression." Anticancer Res. 18. 2015-2020 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ise Y, Yanagawa H, Hirose T, TaniK, Yano S, Suzuki Y, Takeuchi E, ManiwaK, Shimizu E, Ogushi F, Sano T and Sone S: "An autopsy case of cytokeratin 7-positive minute adenocarcinoma of the lung with systemic metastases." Intern Med. 37. 766-769 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshida S, Shimizu E, Sano T, Uyama T, Kawanishi M, Nakamura Y and Sone S: "Synchronous small cell carcinoma and adenocarcinoma of the lung representing different retinoblastoma tumor supperssor protein status." Int J Clin Oncol. 3. 326-329 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Moriguchi S, Kato M, Sakai K, Yamamoto S and Shimizu E: "Exercise training restores the decreased cellular immune function in obese Zucker rats via improvement of GLUT-1 expression." J Appl Physiol. 84. 311-317 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Moriguchi S, Kato M, Sakai K, Yamamoto S and Shimizu E: "Decreased mitogen response of splenic lymphocytes in obese Zucker rats is associated with the decreased expression of glucose transporter-1 (GLUT-1)." Am J Clin Nutr. 67. 1124-1129 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Houchi H, Yoshizumi M, TsuchiyaK, Hirose M, Kitagawa T, Kujime T, ShimizuE, Niwa Y, Minakuchi K and Tamaki T: "Endothelin-1 stimulates sodium-dependent calcium efflux from bovine adrenal chromaffin cells in culture." Br J Pharmacol. 125. 55-60 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hirose M, Shimizu E, Nakanishi H, Shinohara A, Sone S and Kuroda Y: "Expression level of G1-cyclins and cell proliferation in human cultured leukemia/lymphoma cell lines." Int J Oncol. 12. 841-846 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kondo K, Miyoshi T, Hino N, Shimizu E, Masuda N, Takada M, Uyama T andMonden Y: "High frequency expressions of CD44 standard and variant forms in non-small cell lung cancers, but not in small cell lung cancers." J Surg Oncol. 69. 128-136 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamamoto A, Shimizu E, TakeuchiE, Doi H, Bando H,Ogura T and Sone S: "Infrequent presence of anti-c-myc antibodies and absence of c-Myc oncoprotein in sera from lung cancer patients." Oncology. 56. 129-133 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Namikawa O, Shimizu E, SumitomoK and Some S: "Analysis of antibodies to p16INK4A tumor suppressor gene products in lung cancer patients." Int J Oncol. 14. 681-685 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshimoto K, Tanaka C, MoritaniM, Shimizu E, Yamaoka T, Yamada S, SanoTand Itakura M: "Infrequent detectable somatic mutations of the RET and glial cell line-derived neurotrophic factor (GDNF) genes in human pituitary adenomas." Endocrine J. (in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shimizu E: "Oncogene" Naikagakusho. 84-88 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shimizu E: "Chemical carcinogens" Naikagakusho. 81-84 (1999)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-12-08  

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