1998 Fiscal Year Final Research Report Summary
Analysis of Surfactant-associated Proteins in injured lungs
| Project/Area Number |
09670626
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Respiratory organ internal medicine
|
|---|
| Research Institution | DOKKYO UNIVERSITY SCHOOL OF MEDICINE |
|---|
Principal Investigator |
UEDA Takashi Dokkyo University School of Medice, Lecturer, 医学部, 講師 (80213354)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SERIZAWA Yoshimoto Instructor, 医学部, 助手 (60306181)
NAKAZIMA Hirokazu Instructor, 医学部, 助手 (10275753)
|
|---|
| Project Period (FY) |
1997 – 1998
|
| Keywords | Surfactant / Surfactant Protein A / injury lung / Bronchial Asthma / Chemotactis activity / Apoptosis / Eosinophil / Cytokine |
|---|
| Research Abstract |
We investigated suffactant system in acute lung injury and asthmatic lungs. We found that suffactant protein A (SP-A) could stimulate chemotaxis of bronchial epithelial cells, suggesting that SP-A might play a role in lung repair following injury as a chernoattractant. We also reported that altered surfactant system and metabolism in rat lungs injured by LPS instillation. We also reported compositional and functional changes of surfactant in a guinea pig model of chronic asthma and increased levels of SP-A in the airway in patients with bronchial asthma. The interactions between surfactant and eosinophils were also studied. We demonstrated surfactant could induce apoptosis of eosinophils, surpress IL-8production by eosinophils and inhibit ECP degranulation. All these new findings must open a new array to study the involvement of surfactant in the pathogenesis of bronchial asthma and acute lung injury.
|
