2000 Fiscal Year Final Research Report Summary

Treatment of ischemic neuropathy especially with turning point.

Research Project

Project/Area Number	09670677
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Neurology
Research Institution	KINKI UNIVERSITY
Principal Investigator	TAKAHASHI Mitsuo Kinki University School of Medicine, Department of Neurology, Professor., 医学部・附属病院, 教授 (20028492)
Project Period (FY)	1997 – 2000
Keywords	Ischemic neuropathy / Nerve blood flow / FK506 / Immunosuppressant / Microspheres / Neuro-protect / aging / vaso-reactivity
Research Abstract	In 1999, we studied the influence of the vaso-constricting agents(noradrenaline, endothelin-1 and angiotensin II)in Sprague-Dawley rats aged 2, 6 and 24 months by evaluating epineuria arteriolar vasoreactivity in response to superfused test agents. Nerve blood flow(NBF)was decreased and vascular resistance(VR)was increased compared with 2- and 6-month-old rats. All of the constricting agents reduced significantly with age. These results suggest that during aging, there is decline of vasoconstrictive response to noradrenaline, endothelin-1 and angiotensin II in peripheral nerve and that these changes may be due to altered function of receptors. In resucue of ischemic neuropathy, we have to consider of aging factor also.

(4 results)