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2000 Fiscal Year Final Research Report Summary

Vector analysis of atherogenic wall shear stress with magnetic resonance velocity mapping

Research Project

Project/Area Number 09670701
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionUniversity of Tokyo

Principal Investigator

SUZUKI Jun-ichi  University of Tokyo, Health Servoce Center, Assistant Professor, 保健管理センター, 講師 (50260485)

Co-Investigator(Kenkyū-buntansha) TOYO-OKA Teruhiko  University of Tokyo, Health Servoce Center, Professor, 保健管理センター, 教授 (00146151)
Project Period (FY) 1997 – 2000
Keywordswall shear stress / maqnetic resonance velocity mapping / atheroscrelosis
Research Abstract

Low wall shear stress and its large oscillation accelerate atherosclerotic process. Wall shear stress is the product of wall shear rate and blood viscosity coefficient. It has been impossible to measure in vivo wall shear rate that is defined as spatial derivative of near wall blood flow velocity. Magnetic resonance velocity mapping can provide digital information on blood flow velocity for each pixel. Therefore, with this technique the following results were obtained by analyzing three-dimensional vector of wall shear rate.
1) At the inner wall of the distal portion of the aortic arch, the shear rate was smallest and the oscillation was largest indicating that this anatomical portion was the most susceptible to hemodynamical atherogenesis.
2) At the bifurcation of the abdominal aorta, outer wall shear rate was smaller than inner one, and oscillation of outer wall shear rate was larger than that of inner wall shear rate demonstrating the higher risk of atherogensis at the outer wall of the bifurcation.
Thus three-dimensional vector analysis of wall shear rate with magnetic resonance velocity mapping can noninvasively detect the high rist portion susceptible to atherosclerosis.

  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] Suzuki J-i, et al.: "Vector analysis of the hemodynamics of atherogenesis in the human thoracic aorta with use of MR velocity mapping"AJR. 171. 1285-1290 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Suzuki J-i, et al.: "Evaluation of the heart with magnetic resonance imaging"Jpn Heart J. 41. 417-424 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Suzuki J-i, et al.: "Screening and/or follow-up with coronary magnetic resonance angiography"Radiography. 6. 189-197 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 鈴木順一: "心臓MRIテキスト"南江堂. 37 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Suzuki J-i et al.: "Screening and/or follow-up with coronary magnetic resonance angiography : comparison between two-dimensional and three-di mensional teckniques."Radiography. 6. 189-197 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki J-i et al.: "Evaluation of the heart with magnetic resonance imaging."Jpn Heart J. 41. 417-424 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki J-i, et al.: "Morphological onset and early diagnosis in apical hypertrophic cardiomyopathy : a long-term analysis with nuclear magnetic resonance imaging."J Am Coll Cardiol. 133. 146-151 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki J-i et al.: "Vector analysis of the hemodynamics of atherogenesis in the human thoracic aorta with use of MR velocity mapping."AJR. 171. 1285-1290 (1998)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2002-03-26  

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