1998 Fiscal Year Final Research Report Summary
Multiple mechanisms in the long-QT Syndrome.
| Project/Area Number |
09670721
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | OKAYAMA Universty |
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Principal Investigator |
OHE Tohru OKAYAMA Universty, Medical School, Professor, 医学部, 教授 (70263556)
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| Co-Investigator(Kenkyū-buntansha) |
EMORI Tetsuro OKAYAMA Universty, Medical School, Assistant, 医学部, 助手 (20273964)
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| Project Period (FY) |
1997 – 1998
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| Keywords | long QT Syndrome / electrocardiogram / gene diagnosis |
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| Research Abstract |
1)Effectsof beta blocker therapy on the dynamic QT/RR relation in patients with long QT syndromeduring 24-hour Holter ECG monitoring.
Holter ECG recordings before and after the therapy were obtained from long QT syndrome(LQTS) patients. The QT/RR relation was analyzed by our original computeralgorithm with automatic measurement of the QT interval. Patients with LQTS have an abnormality in the dynamic relationship between the QT and RR intervals (QT/RR relation). beta blocker therapy did not affect the unique QT/RR relation, which reflectsan intrinsic abnormality of the ventricular repolarization in LQTS patients (Annals of Noninvasive Electrocardiology. 1997 : 2 : 40-46).
2)Dispersion of regional wall motion abnormality in patients with long QT syndrome.
We examined the left ventricularregional wall motion abnormality and evaluated dispersion of this abnormality in patients with long QT syndrome(LQTS) . Left ventricularshort axis images at basal and middle levels were recordedon videotape and digitised to reconstructdigitised M mode echocardiograms, from which left ventricular wall thickness curves were obtained. The wall thickening time (ThT) was defined as the period in which the instantaneous wall thickness exceeded 90% of the maximum wall thickness. ThT was measuredat three segmentsin each of the septal and free wall sides of the left ventricle, a total of 12 segments. The averaged ThT in the LQTS patients was longer than in the control subjects (p<0.005). A significanctcorrelation was found between QT dispersion and ThT dispersion ( r=0.84, p<0.001). There is not only electrical but also mechanical dispersion in the left ventricle of LQTS patients. Regional assessment of ventricular wall motion may allow quantification of the spatial variation of wall motion abnormality( Heart. 1998 : 80 : 245-250).
3)We reviewed about the molecular classification of the long QT syndromein Japanese(Kokyu to Junkan 1998 : 46 : 383-389).
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