Role of myocyte nitric oxide in the contractile dysfunction in heart failure.

1998 Fiscal Year Final Research Report Summary

• Project/Area Number: 09670724
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: KYUSHU UNIVERSITY FACULTY OF MEDICINE
• Principal Investigator: TSUTSUI Hiroyuki KYUSHU UNIVERSITY,FACULTY OF MEDICINE,ADJUNCT ASSISTANT PROFESSOR, 医学部, 講師 (70264017)
• Co-Investigator(Kenkyū-buntansha): TAGAWA Hirofumi KYUSHU UNIVERSITY,FACULTY OF MEDICINE,ASSISTANT PROFESSOR, 医学部, 助手 (60304797) ; OHARA Yuichi KYUSHU UNIVERSITY,FACULTY OF MEDICINE,ASSISTANT PROFESSOR, 医学部, 助手 (90185364) ; EGASHIRA Kensuke KYUSHU UNIVERSITY,FACULTY OF MEDICINE,ASSISTANT PROFESSOR, 医学部, 講師 (60260379)
• Project Period (FY): 1997 – 1998
• Keywords: Heart failure / Nitric oxide / Myocyte / Contractility / beta-adrenergic receptor

Research Abstract

Heart failure is associated with the contractile dysfunction and theimpaired responsiveness to beta-adrenergic stimulation at the myocyte level of unknown causes. Heart failure increased nitric oxide (NO) in the myocardium, which was responsible for the diminished contractile responses to beta-adrenergic stimulation. The association of NO and contractile abnormalities was recognized in the animal model of failing heart and increased NO induction might have pathophysiological significance for the contractile defects in congestive heart failure.

Research Products

• [Publications] Tsutsui H,et al.: "Alterations in sarcoplasmic reticulum calcium-storing proteins in pressure-overload cardiac hypertrophy." Am J Physiol. 272. H168-H175 (1997)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Yamamoto S,et al.: "Role of myocyte nitric oxide in β-adrenergic hyporesponsiveness in heart failure." Circulation. 95. 1111-1114 (1997)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Namba T,et al.: "Regulation of fibrillar collagen gene expressin and protein accumulation in volume overload cardiac hypertrophy." Circulation. 95. 2448-2456 (1997)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Ishibashi Y,et al.: "Negative inotropic effect of basic fibroblast growth factor (bFGF) on adult rat cardiac myocyte." Circulation. 96. 2501-2504 (1997)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Takahashi M,et al.: "Role of microtubules in the contractile dysfunction of myocytes from tachycardia-induced dilated cardiomyopathy." J Mol Cell Cardiol. 30. 1047-1057 (1998)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Igarashi-Saito K,et al.: "Role of sarcoplasmic reticulum calcium-ATPase gene expression in the contractile dysfunction of tachycardia-induced heart failure." Am J Physiol. 275. H31-H40 (1998)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Takahashi M,et al.: "Microtubules are Involved for the Initiation of Cardiac Hypertrophy during Pressure Overload." Am J Physiol. 275. H341-H348 (1998)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Yamamoto S,et al.: "Role of microtubules in the viscoelastic properties of isolated cardiac muscle." J Mol Cell Cardiol. 30. 1841-1853 (1998)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Kinugawa S,et al.: "Positive inotropic effect of insulin-like growth factor-1 IGF-1 on normal and failing cardiac myocyte." Cardiovasc Res. in press.
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Tsutsui H,Ishibashi Y,Imanaka-Yoshida K,Yamamoto S,Yoshida T,Sugimachi M,Urabe Y,Takeshita A: "Alterations in sarcoplasmic reticulum calcium-storing proteins in pressure-overload cardiac hypertrophy" Am J Physiol. 272. H168-H175 (1997)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Yamamoto S,Tsutsui H,Tagawa H,Saito K,Takahashi M,Tada M,Yamamoto M,Katoh M,Egashira K,Takeshita A: "Role of myocyte nitric oxide in beta-adrenergic hyporesponsiveness in heart failure" Circulation. 95. 1111-1114 (1997)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Namba T,Tsutsui H,Ishibashi Y,Tagawa H,Takahashi M,Saito K,Kozai T,Usui M,Imanaka-Yoshida K,Imaizumi T,Takeshita A: "Regulation of fibrillar collagen gene expression and protein accumulation in volume overload cardiac hypertrophy" Circulation. 95. 2448-24564 (1997)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Ishibashi Y,Urabe Y,Tsutsui H,Kinugawa S,Sugimachi M,Takahashi M,Yamamoto S,Tagawa H,Sunagawa K,Takeshita A: "Negative inotropic effect of basic fibroblast growth factor (bFGF) on adult rat cardiac myocyte" Circulation. 96. 2501-2504 (1997)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Takahashi M,Tsutsui H,Kinugawa S,Igarashi-Saito K,Yamamoto S,Tagawa H,Imanaka-Yoshida K,Egashira K,Takeshita A: "Role of microtubules in the contractile dysfunction of myocytes from tachycardia-induced dilated cardiomyopathy" J Mol Cell Cardiol. 30. 1047-1057 (1998)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Igarashi-Saito K,Tsutsui H,Ishibashi Y,Tagawa H,Takahashi M,Saito K,Kozai T,Usui M,Imanaka-Yoshida K,Imaizumi T,Takeshita A: "Role of sarcoplasmic reticulum calcium-ATPase gene expression in the contractile dysfunction of tachycardia-induced heart failure" Am J Physiol. 275. H31-H40 (1998)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Takahashi M,Tsutsui H,Tagawa H,Kinugawa S,Ishibashi Y,Igarashi-Saito K,Imanaka-Yoshida K,Takeshita A: "Microtubules are Involved for the Initiation of Cardiac Hypertrophy during Pressure Overload" Am J Physiol. 275. H341-H348 (1998)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Yamamoto S,Tsutsui H,Takahashi M,Ishibashi Y,Tagawa H,Imanaka-Yoshida K,Saeki Y,Takeshita A: "Role of microtubules in the viscoelastic properties of isolated cardiac muscle" J Mol Cell Cardiol. 30. 1841-1853 (1998)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Kinugawa S,Tsutsui H,Igarashi-Saito K,Takahashi M,Tagawa H,Egashira K,Takeshita A: "Positive inotropic effect of insulin-like growth factor-1 IGF-1 on normal and failing cardiac myocyte" Cardiovasc Res. (in press).
  • Description: 「研究成果報告書概要(欧文)」より