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1998 Fiscal Year Final Research Report Summary

Analysis of molecular response in the heart to emotional stress

Research Project

Project/Area Number 09670740
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionWakayama Medical Collage

Principal Investigator

UEYAMA Takashi  Wakayama Medical Collage, Assistant professor, 医学部, 講師 (50264875)

Co-Investigator(Kenkyū-buntansha) SENBA Emiko  Wakayama Medical Collage, Professor, 医学部, 教授 (00135691)
Project Period (FY) 1997 – 1998
KeywordsEmotional stress / Heart / Electrocardiogram / Immediate early genes / Natriuretic peptide / Heat shock protein / Adrenoceptor / Signal transduction
Research Abstract

Emotional stress, and associated activation of adrenergic system underlie cardiac accidents. Immobilization stress of rats, which produces activation of the sympatho-adrenal medullary system, induced ischemic electrocardiographic changes. Corresponding to these changes, immediate early genes/transcriptional factors (IEGs) were expressed in the smooth muscle cells of coronary arteries, enodothelial cells and myocardium. Furthermore, mRNA for heat shock protein 70 was induced in the aortic and coronary smooth muscles cells from 30min to 3h after onset of stress. Natriuretic peptide genes (ANP and BNP) were also upregulated. Sequential expression of these genes can be considered as an adaptive response to stress. Not a single but synergistic blocking of alpha and beta adrenoceptors blocked the IEGs expressions elicited by stress. Either alpha or beta agonist upregulated IEGs in the perfused heart. Activation of alpha or beta adrenoceptors is the primary trigger of stress-induced molecular and electrophysiological changes in the heart. Crosstalk of signal transduction between downstream of alpha and beta adrenoceptors in these cardiac cells is also suggested.

  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] Ueyama. T. et al.: "Immobilization stress induces c-fos and c-jun immediate early genes expression in the heart"Life Sciences. 59(4). 339-347 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hatakeyama S. et al.: "Nitric oxide synthase-containing magnocellular neurons of the rat hypothalumus syntesize oxytocin and vasopressin"Journal of Chemical Neuroanatomy. 11. 243-256 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Umemoto S. et al.: "Chronic glucocorticoid administration as well as repeated stress affects the subsequent acute immobilization"Neuroscience. 80(3). 763-773 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ueyama. T. et al.: "Immobilization stress reduced the exression of neurotrophins and their receptors in the rat brain"Neuroscience Research. 28. 103-110 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Senba. E. et al.: "Stress-induced expression of immediate early genes in the brain and perepheral organs of the rat"Neuroscience Research. 29. 183-207 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ueyama. T. et al.: "Water immersion-restraint stress induces exression of immediate-early genes in gastrointestinal tract of rats"American Journal of Physiology. 275. G287-G295 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Saika M. et al.: "Prostacyclin analog prevents stress-induced expression of immediate early genes and gastric mucossal lesions in"Life Sciences. 64(21). 235-240 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ueyama. T. et al.: "Emotinal stress induces expression of immediate early genes in the rat heart via activation of alpha-and beta-"American Journal of Physiology. (in press). (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ueyama. T. et al.: "Effects of ethanol on the stress-induced expression of NGFI-A mRNA in the rat brain"Alcohol. (in press). (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takashi Ueyama: "Immobilization stress induced c-fos and c-jun immediate early genes expression in the heart"Life Sci.. 659(4). 339-347 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shuji Hatakeyama: "NO Synthease containing magnocellular neurons of the rat hypothalamus synthesize oxtocin and vasopressin and express Fos following stress stimuli"J. Chem. Neuroanat.. 11. 243-246 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Santa Umemoto: "Glucocorticoid administration as well as repeated stress affects the subsequent acute immobilization stress-induced expression of immediate early genes but not that of NGFI-A"Neuroscience. 80. 763-773 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takashi Ueyama: "Immobilization stress reduced the expression of neurotrophins and their receptors in the rat brain"Neurosci. Res.. 28. 103-110 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Emiko Senba: "Stress-induced expression of immediate early genes in the brain and peripheral organs of the rat (Review)"Neurosci. Res.. 29. 183-207 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takashi Ueyama: "Water immersion/restraint stress induces expression of immediate early genes in the gastrointestinal tract of rats"Am. J. Physiol.. 275(2 Pt 1). G287-G295 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takashi Ueyama: "Effects of ethanol on the stress-induced expression of NGFI-A mRNA in the rat brain"Alcohol. (in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Misako Saika: "Prostacyclin prevents stress-induced expression of immediate early genes and gastric mucosal lesions in the rat stomach"Life Sci.. 64. PL235-240 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takashi Ueyama: "Emotional stress induces expression of immediate early genes in the rat heart via activation of alpha- and beta- adrenoceptors"Am. J. Physiol. (in press).

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2001-10-23  

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