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1999 Fiscal Year Final Research Report Summary

Evaluation of genetical factor in the Japanese is chemic heart disease

Research Project

Project/Area Number 09670743
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionIwate Medical University

Principal Investigator

NAKAI Kenji  School of Medicine, Iwate Medical University, Associate Professor, 医学部, 助教授 (90146035)

Co-Investigator(Kenkyū-buntansha) NAKAI Keiko  School of Medicine, Iwate Medical University, Assisstant Professor, 医学部, 講師 (40227723)
OHHIRA Atsushi  School of Medicine, Iwate Medical University, Assisstant Professor, 医学部, 助手 (60275534)
Project Period (FY) 1997 – 1999
Keywordsmyocardial infarction / gene / apolipolrotein E / angiotensin II type 1 receptor / methylenetetrahydrofolate reductase / ecNOS
Research Abstract

Coronary artery disease including acute myocardial infarction is a major cause for cardiac sudden death. The pathogenesis and genetical risk factor of coronary artery disease and acute myocardial infarction have not been fuilly elucidated. The clinical research regarding genetical factors in the Japanese were worthy of note in the world, because the frequencies of several gene polymorphism were different with those in Caucasian. The purpose of this study is to evaluate the significance of genetical factors such as apolipoprotein E (apo E), angiotensin II type 1 receptor, ecNOS, and methylenetetrahydrofolate reductase (MTHFR) in the occurrence of myocardial infarction.
Results: 1) The frequency of polymorphism of apo E ε4 allele and ATR1 All66C mutation [AC+CC] in the Japanese healthy population was lesser than those in Caucasian healthy population. 2) The frequency of apo E ε 4 allele and ATR1 A1166C mutation [AC+CC], esNOS 4a/a with tandem repeat, and MTHFR alanine/valine (A/V) caused by C677T mutation in the myocardial infarction were greater than those in Japanese healthy population (apo E; Nakai et al, Coronary Artery Dis, 1999). 3) Thee levels of concentration of homocysteine in MTHFR gene VV type was higher than that in other AV and AA genotype (11.6 ± 5.6 μmol/L in VV type, 8.9 ± 4.1 μmol/L in AV type and 8.6 ± 3.3 μmol/L in AA type) (Nakai K et al: Coronary Artery Dis, 1999). 4) The frequency of ATRI A1166C mutation [AC+CC] in the myocardial infarction was higher than that in healthy population (Fusazaki et al; Eur heart J, 1999).
In conclusion, apo E e4 allele, A1166C mutation [AC+CC], MTHFR geneVV type were predisposition for myocardial infarction. In future, these genetical analysis enable to indicate for primary or secondary prevention for myocardial infarction or coronary artery disease.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Nakai K, Fusazaki T, et al: "Genetic polymorphism of 5, 10-methylenetetrahydofolate increases risk of myocardial infarction and its correlates to elevated levels of homocysteine in the Japanese general population"Coronary Artery Dis. 11. 47-51 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakai K, Fusazaki T, et al: "Polymorphism of the apolipoprotein E and angiotensin I converting enzyme genes in the Japanese patients with myocardial infarction"Coronary Artery Dis.. 9. 329-334 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 中居賢司、大平篤志、他: "虚血性心疾患の早期検出法と発症に関連する遺伝子の検索"日本循環器管理研究協議会雑誌. 33・3. 179-185 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 房崎哲也、中居賢司、他: "アンジオテンシンII受容体遺伝子型の日本人心筋梗塞症での意義"Jpn Circ J. 62. 398 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakai K, Fusazaki T, et al: "Significance of gene polymorphism of the renin-angiotensin system apo E, and MTHFR reductase to myocardial infarction"Eur Heart J. 19. 286 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fusazaki T, Nakai K, et al: "The significance of the angiotensin II type 1 receptor gene polymorphism in myocardial infarction in the Japanese"Eur Heart J. 19. 286 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakai K, Fusazaki T, et al: "Genetic polymorphism of 5, 1O-methylenetetrahydofolate increases risk of myocardial infarction and its correlates to elevated levels of homocysteine in the Japanese general population"Coronary Artery Dis. 11. 47-51 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakai K, Fusazaki T, et al: "Polymorphism of the apolipoprotein E and angiotensin I converting enzyme genes in the Japanese patients with myocardial infarction"Coronary Artery Dis. 9. 329-334 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakai K, Fusazaki T, et al.: "Significance of gene polymorphism of the renin-angiotensin system apo E, and MTHFR reductase to myocardial infarction in the Japanese."Eur Hert J. 19. 286 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakai K, Fusazaki T, Ohira A, et al.: "Angiotensin-converting enzyme, angiotensinogen, angiotensin II type 1 receptor gene polymorphisms, and common caroid artery intima-media thickness in the Japanese genereal population."Eur Hert J. 19. 245 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fusazaki T, Nakai K, et al.: "he significance of the angiotensin II type 1 receptor gene polymorphism in myocanlial infarction in the Japanese"Eur Hert J. 19. 286 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakai K, Ohira A, et al.: "Early detection of ischemic heart disease and the evaluation of genetical factor"J Jpn Association for Cerebrocardiovascular Disease Control. 33. 179-185 (1998)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2001-10-23  

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