1998 Fiscal Year Final Research Report Summary
Diagnosis and treatment for zinc deficiency anemia
| Project/Area Number |
09670818
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kumamoto University |
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Principal Investigator |
NISHIYAMA Soroku Kumamoto University, School of Medicine, Department of Pediatrics, Assistant Professor, 医学部・附属病院, 講師 (20145311)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Toshiro Kumamoto University, School of Medicine, Department of Pediatrics, Assistance, 医学部, 助手
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| Project Period (FY) |
1997 – 1998
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| Keywords | Anemia / Zinc deficiency / Iron deficiency anemia / Zinc / Zinc deficiency anemia / 亜鉛欠乏性貧血 |
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| Research Abstract |
Based on the result of total body zinc clearance in 37 females with anemia (age 22.3*4., years), diagnosis of zinc deficiency anemia seems like to identify as follows ; 1) hemoglobin levels below 12.Og/dl, red cell numbers below 380*104/mm^3, TIBC below 380 mug/dl with normocytic normochromic anemia, 2) serum zinc levels is almost normal, 3) excluding other disorders with normocytic normochromic anemia, 4) often accompanied by iron deficiency anemia. Fifty-two Japanese women who were selected from a health examination survey on 6200 women, had hemoglobin concentrations below 12.0g/dl, total iron binding capacity (TIBC) below 380 mug/dl and a fairly normocytemia. These 52 were grouped into three and we then compared the hematological status before and after iron (group A) or Zn (group B) or iron plus Zn (group C) supplementation. After treatment , concentrations of hemoglobin (Hb) increased slightly in groups A and B, but not statistically. In group C, Hb levels were significantly increased.
Zn status to some extent can account for hematological abnormalities in middle aged women. At least 5.0% of middle aged Japanese women may have Zn deficiency. Normocytic anemia with low TIBC levels may serve as a good indicator of a marginal Zn deficiency.
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