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1998 Fiscal Year Final Research Report Summary

Intervention of'non-insulin-dependent diabetes mellitus (NIDDM) by intravenous injection of 8-methoxypsoralen plus ultraviolet A (PUVA) -treated syngeneic splenocytes in KK-Ay mice

Research Project

Project/Area Number 09670902
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionKansai Medical University

Principal Investigator

OHNISHI Yoko  Kansai Medical Universtiy, Department of Dermatology, Assintant, 医学部, 助手 (60278611)

Co-Investigator(Kenkyū-buntansha) HORIO Takeshi  Kansai Medical University, Department of Dermatology, Professor, 医学部, 教授 (90026914)
Project Period (FY) 1997 – 1998
KeywordsPHOTOCHEMOTHERAPY / ANIMAL MODEL / DIABETES MELLITUS / diabetes mellitus
Research Abstract

KK-Ay mice develop spontaneously positive glucosuria, impaired glucose tolerance, hyperinsulinemia, and hyperglycemia after 5-week (wk)-old of age. The effects of photochemotherapy on glucose intolerance were examined in KK-Ay mice. Once a week, a recipient KK-Ay mouse had intravenous injections of syngeneic splenocytes from obert-diabetic mice and treated with 8-rn ethoxypsoralen plus ultraviolet A light (PUVA). Intraperitoneal glucose tolerance tests (ipGTTs) revealed that the means of serum glucose and insulin levels in the PUVA-treated group were significantly lower than those of control groups, when recipients were older than 8-wk-old. Futherm ore, single injection with more than 1x107 cells from prediabetic 4-wk-old mice were also effective. Although the pathomechanism remains to be clarified, PUVA is an effective candidate to intervent the progression of NIDDM in KK-Ay m ice.

  • Research Products

    (5 results)

All Other

All Publications (5 results)

  • [Publications] Ohnishi-Inoue Y: "Immunoprevention of non-insulin-dependent diabetes mellitus (NIDDM) in KK-Ay mice by 8-methoxypsoralen plus ultraviolet A light (PUVA) treatment." J Invest Dermatol. 110. 698 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ohnishi-Inoue Y,Horio T.: "Immunoprevention of non-insulin-dependent diabetes mellitus (NIDDM) in KK-Ay mice by 8-methoxypsoralen plus ultraviolet A light (PUVA) treatment." JInvest Dermatol. 110. 698 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshimura-Mishima M,Akamatsu H,Namura S,Horio T.: "Suppressive effect of ultraviolet (UVB and UVA) radiation on superantigen production by staphylococcus aureus." JDermatol Sci. 19. 31-36 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Horio T.: "Skin disorders that improve by exposure to sunlight." Clin Dermatol. 16. 59-65 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sasai-Takedatsu, Kojima T et al.: "Reduction of staphylococcus aureus in atopic skin lesions with acid electrolytic water-a new therapeutic strategy for atopic dermatitis." Allergy. 52. 1012-1016 (1997)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-12-08  

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