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1999 Fiscal Year Final Research Report Summary

Development of system and software for precise brain functional mapping

Research Project

Project/Area Number 09670939
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionEhime University

Principal Investigator

MURASE Kenya  Ehime University Hospital, Assistant Professor, 医学部・附属病院, 講師 (50157773)

Project Period (FY) 1997 – 1999
Keywordssystem / software / brain functional mapping / nuclear medicine / MRI / fMRI / MRI
Research Abstract

Recently, high-order brain functions have been studied using nuclear medicine imaging and/or functional magnetic resonance imaging (fMRI). To perform these studies, it is necessary to precisely register the brain functional images obtained by nuclear medicine imaging or fMRI to the morphological images obtained by magnetic resonance imaging (MRI). In this research project, we developed a system and software with which the registration between the two images can be performed precisely. In 1997, we developed a basic system and software using the purchased workstation and C-compiler. In the software developed in this project, we used the stochastic sign change (SSC) criterion and nonlinear least-squares method for maximizing the similarity between the two images. In 1998, we investigated the availability of our software comparing it with the software generally used, and we found that our software was superior to the conventional one in accuracy. In 1999, we applied our system and software to the clinical data and found that they were useful and applicable in clinical settings. We also applied our software to other areas such as the measurement of cerebral blood flow using single photon emission computed tomography (SPECT), and we found that our software can also be used in other areas.

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] Murase K,Fujioka H,Inoue T,Ishimaru Y,Akamune: "Measarement of blood radioactivity for quautitication of cerebral blood flow"Journal of Nuclear Medicine Technology. 26. 191-195 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Murase K,Mochizuki T,Kikuchi T,Ikezoe J: "Kinetei parameter estimation from compartment models using a genetic algorithm"Nuclear Medicine Communications. 20. 925-932 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Murase K,Tsuda T,Mochizuki T,Ikezoe J: "Hepatic extraction fraction of hepatobiliary rodiopherma-ccuticals measured using spectral analysis"Nuclear Medicine Communications. 20. 1041-1046 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Murase K,Inoue T,Fujioka H,Ishimaru Y: "An alternative approach to estinatin of the brain perfuston index"European Journal of Nuclear Medicine. 26. 1333-1339 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mochizuki T,Murase K,Koyama Y,Higashino H: "Two-and,three-dimensional CT veutiolograpry a new application of helical CT"American Journal of Roentgenology. 174. 203-208 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nagao M,Murase K,Sakai S,Yasuhara Y: "Quantitative analysis of Technegas SPECT:evaluction of regicnal severity of emplysema"Journal of Nuclear Medicine. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 村瀬研也: "放射線機器工学(X線CT)"医歯薬出版(印刷中). (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 村瀬研也: "放射線機器工学(核医学機器)"医歯薬出版(印刷中). (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Murase K, Fujioka H, Inoue T, Ishimaru Y, Akamune A: "Measurement of blood radioactivity for quantification of cerebral blood flow"Journal of Nuclear Medicine Technology. Vol.26. 191-195 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Murase K, Mochizuki T, Kikuchi T, Ikezoe J: "Kinetic parameter estimation from compartment models using a genetic algorithm"Nuclear Medicine Communications. Vol.20. 925-932 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Murase K, Tsuda T, Mochizuki T, Ikezoe J: "Hepatic extraction fraction of hepatobiliary radiopharmaceuticals measured using spectral analysis"Nuclear Medicine Communications. Vol.20. 1041-1046 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Murase K, Inoue T, Fujioka H. Ishimaru Y, Akaimune A: "An alternative approach to estimation of the brain perfusion index"European Journal of Nuclear Medicine. Vol.26. 1333-1339 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mochizuki T, Murase K, Koyama Y, Higashino H, Doi M. Shimizu K: "Two- and three-dimensional CT ventriculography - a new application of helical CT"American Journal of Roentgenology. Vol.174. 203-208 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nagao M, Murase K, Ichiki T, Sakai S, Yasuhara Y, Ikezoe J: "Quantitative analysis of Technegas SPECT : evaluation of regional severity of emphysema"Journal of Nuclear Medicine. (in press).

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2001-10-23  

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