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1999 Fiscal Year Final Research Report Summary

Study of Automatic Information Processing in Schizophrenia according to Temporal Window of Integration Theory

Research Project

Project/Area Number 09670972
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionHirosaki University

Principal Investigator

YABE Hirooki  Hirosaki University Hospital, Assistant Professor, 医学部・附属病院, 講師 (60210316)

Co-Investigator(Kenkyū-buntansha) KANEKO Sunao  Hirosaki University School of Medicine, Professor, 医学部, 教授 (40106852)
KURIBAYASHI Michito  Hirosaki University Hospital, Instructer, 医学部・附属病院, 助手 (80261436)
SHINOZAKI Naoko  Hirosaki University Hospital, Instructer, 医学部・附属病院, 助手 (20292162)
Project Period (FY) 1997 – 1999
KeywordsMMN / Auditory Sensory Memory / Temporal Integration / Electroencephalography / Magnetoencephalography
Research Abstract

Mismatch negativity (MMN) component of the event-related brain potentials (ERPs) reflects the memory process related to the automatic information processing. We reported the mechanism of "Temporal Window of Integration (TWI)" in auditory sensory memory as reflected by MMN (Yabe et.al., NeuroReport, 1997). On the other hand, several studies indicated that deficits of cognitive function in schizophrenia were also reflected in the impaired generation of MMN.In our previous studies, infrequently omitting one stimulus from a homogeneous sound sequence only elicited an MMN when SOA was shorter than 160-170 ms, the duration of TWI (Magnetoencephalography : MEG ; Yabe et.al., Psychophysiology, 1998, Yabe et.al., EEG journal, suppl. 40, 1999 ; 6th IEPS : Okazaki Award). Furthermore, we found that automatic detection sensitivity should decline nonlinearly toward the end of TWI (Yabe et.al., Cog.Brain Res., in press) and that the mechanism of Stream Segregation be more primary than that of TWI (Y … More abe et.al., Brain Res. Interactive, in press). Both results were presented in the symposium of ICON-7(1999, Budapest). We also investigated sound grouping in human brain as reflected by MMN (Shinozaki et.al., NeuroReport, 2000). We reported that Median Method should be effective in eliminating infrequent artifacts and identifying the signals blurred by latency jitter and uncertain occurrence (Yabe, Electroencephr. Clin. Neurophysiol., 1993 ; Yabe, BRMIC, 1998). We identified the equivalent of MMN in somatosensory modality (Shinozaki et.al., Cog.Brain Res., 1998). We reported that the administration of neuroleptic drugs decreased the arousal level, as reflected in a reduction of early CNV amplitude (Sato et.al., Schizo.Res., 1999). Finally, we found that the TWI mechanism might be impaired in schizophrenia (Symposium of MMN 2000, Barcerona, 2000). Additionally, we started the studies concerning the language MMN (Koyama et al., Cog. Brain Research, 2000 ; Koyama et al., NeuroReport, 2000). Less

  • Research Products

    (35 results)

All Other

All Publications (35 results)

  • [Publications] H.Yabe et al.: "Temporal window of integration revealed by MMN to sound omission"NeuroReport. 8. 1971-1974 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Sato et al.: "Do changes in probability on the MMN have a differents effects in schizophrenic patients ?"Recent Advances in Human Neurophysiology.. 803-808 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Yabe et al.: "Temporal window of integration of auditory information in the human brain"Psychophysiology. 35. 615-619 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Yabe: "Median method for eliminating infrequent artifacts and identifying the signales blurred by latency jitter and uncertain occurence"Special Issues on ERP in BRMIC. 30(1). 68-77 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.Shinozaki et al.: "Somatosensory mismatch response"Cognitive Brain Research. 7. 165-171 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Sato et al.: "The administration of neuroleptic drugs decreased the arousal level, as reflected in a reduction of early CNV amplitude."Shizophrenia Res.. 40(1). 81-86 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Yabe et al: "The duration of the integrating windows it auditory sensory memory."Electroencephalogr Clin Neurophysiol (Suppl). 49. 166-169 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Sato et al.: "The effect of deviant-stimulus probability on the human mismatch process."NeuroReport 11. 11. 3703-3708 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Sutoh et al.: "Event-related desynchronization during an auditory oddball task."Clinical Neurophysiology. 11. 858-862 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Nashida et al.: "Automatic auditory information processing in sleep."SLEEP. 23(6). 821-828 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Koyama et al.: "The masking effect in foreign speech sounds perception revealed by the neuromagnetic responses"NeuroReport. 11. 3765-3769 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Koyama et al.: "Hemispheric lateralization in an analysis of speech sounds Left hemisphere dominance replicated in Japanese subjects"Cog.Brain Research. 10. 119-124 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.Shinozaki et al.: "Mismatch Negativity (MMN) reveals sound grouping in the human brain."NeuroReport. 11. 1597-1601 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Yabe et al.: "Automatic discriminative sensitivity inside temporal window of sensory memory as a function of time."Cog Brain Research. in press (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Yabe et al.: "Organizing Sound Sequences in the Human Brain : The Interplay of Auditory Streaming and Temporal Integration."Brain Research (Interactive Report). in press (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 須藤武之,矢部博興: "持続音の欠落部分によって誘発されたMMNについて"臨床脳波. 41(9). 560-564 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 書間臣治,矢部博興: "ヒバ芳香曝露条件下における健常人のCNV変化"臨床脳波. 41(6). 347-351 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 栗林理人: "精神分裂病患者における注意障害:簡易精神症状評価尺度(BPRS)と随伴陰性変動(CNV)との関連から"臨床脳波. 40(8). 516-522 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 大滝千代子ら: "基準電極の違いがMMN(ミスマッチ陰性電位)計測に与える影響について"臨床脳波. 42(2). 99-102 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 佐藤泰治ら: "精神分裂病患者における前頭葉MMNと側頭葉MMNに対する確率効果の差異について"臨床脳波. 42(7). 415-422 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Yabe, M.Tervaniemi, K.Reonikainen, & R.Naatanen: "Temporal window of integration revealed by MMN to sound omission"NeuroReport. 8. 1971-1974 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Sato, H.Yabe, T.Hiruma, T.Sutoh, N.Shinozaki, T.Nashida, F.Saito and S.Kaneko: "Do changes in probability on the MMN have a differents effects in schizophrenic patients?"Ed.by I.Hashimoto and T.Kakigi ; Recent Advances in Human Neurophysiology.. Elesevier Science B.V.. 803-808 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Yabe, M.Tervaniemi, J.Sinkkonen, M.Huotilainen, R.J.Iimoniemi, and R.Naatanen: "Temporal window of integration of auditory information in the human brain"Psychophysiology. 35. 615-619 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Yabe: "median method for eliminating infrequent artifacts and identifying the signales blurred by latency jitter and uncertain occurence"Special Issues on ERP in BRMIC. 30(1). 68-77 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Shinozaki, H.Yabe, T.Hiruma, T.Sutoh, T.Nashida, and S.Kaneko: "Somatosensory mismatch response"Cognitive Brain Research. 165-171 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Sato, H.Yabo, T.Hiruma, T.Sutoh, N.Shinozaki, T.Nashida, S.Kaneko, F.Saito and Y.Fukushima: "The administration of neuroleptic drugs decreased the arousal level, as reflected in a reduction of early CNV amplitude."Shizophrenia Res.. 40(1). 81-86 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Yabe, Y.Sato, T.Sutoh, T.Hiruma, N.Shinozaki, T.Nashida, F.Saito and S.Kaneko: "The duration of the integrating windows in auditory sensory memory."Functional Neuroscience : Evoked Potentials and Magnetic Fields : Electroencephalogr Clin Neurophysiol 1999. 49(Suppl). 166-169

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Sato, H.Yabe, T.Hiruma, T.Sutoh, N.Shinozaki, T.Nashida, and S.Kaneko: "The effect of deviant-stimulus probability on the human mismatch process"NeuroReport. 11. 3703-3708 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Sutoh, H.Yabe, Y.Sato, T.Hiruma, and S.Kaneko: "Event-related desynchronization during an auditory oddball task."Clinical Neurophysiology. 11. 858-862 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Nashida, H.Yabe, Y.Sato, T.Hiruma, T.Sutoh, N.Shinozaki, and S.Kaneko: "Automatic auditory information processing in sleep"SLEEP. 23(6). 821-828 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Koyama, A.Gunji, H.Yabe, R-A.Yamada, S.Oiwa, R.Kubo, and R.Kakigi: "The masking effect in foreign speech sounds perception revealed by the neuromagnetic responses"NeuroReport. 11. 3765-3769 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Koyama, A.Gunji, H.Yabe, S.Oiwa, R-A.Yamada, R.Kakigi, and R.Naatanen: "Hemispheric lateralization in an analysis of speech sounds Left hemisphere dominance replicated in Japanese subjects"Cog.Brain Research. 10. 119-124 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Shinozaki, H.Yabe, Y.Sato, T.Sutoh, T.Hiruma, T.Nashida, and S.Kaneko: "Mismatch Negativity (MMN) reveals sound grouping in the human brain"NeuroReport. 11. 1597-1601 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Yabe, S.Koyama, R.Kakigi, A.Gunji, M.Tervaniemi, Y.Sato, S.Kaneko: "Automatic discriminative sensitivity inside temporal window of sensory memory as a function of time."Cog Brain Research. (in press)(Date of Acceptance : 06-FEB-2001)..

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Yabe, I.Winkler, I.Czigler, S.Koyama, R.Kakigi, T.Sutoh, H.Tomiharu, S.Kaneko: "Organizing Sound Sequences in the Human Brain : The Interplay of Auditory Streaming and Temporal Integration."Brain Research (Interactive Report). (in press)(Date of Acceptance : 09-FEB-2001)..

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2002-03-26  

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