1998 Fiscal Year Final Research Report Summary
Intracellular signal-transduction in oxidized LDL-induced macrophage growth in arterial wall.
| Project/Area Number |
09671065
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
内分泌・代謝学
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| Research Institution | Kumamoto University |
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Principal Investigator |
SHICHIRI Motoaki Kumamoto Univ.School of Med., Professor and Director, 医学部, 教授 (00028515)
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| Co-Investigator(Kenkyū-buntansha) |
TOYONAGA Tetsushi Kumamoto Univ.School of Med., Assistant Professor, 医学部, 助手 (60295128)
SHIROTANI Tetsuya Kumamoto Univ.School of Med., Assistant Professor, 医学部・附属病院, 助手 (30274715)
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| Project Period (FY) |
1997 – 1998
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| Keywords | Macrophage / Foam Cell / Cell proliferation / Atherosclerosis / Scavenger receptor / Oxidized low density lipoprotein / GM-CSF / Protein kinase C |
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| Research Abstract |
In this project, we demonstrated following findings ;
(1) Endocytic uptake of lysophosphatidylcholine through the scavenger receptor A-I/A-II plays an essential role in oxidized LDL-induced macrophage proliferation.
(2) Rise in intracellular calcium and subsequent activation of protein kinase C by oxidized LDL are involved in oxidized LDL-induced macrophageproliferation.
(3) Induction of GM-CSF by oxidized LDL induces macrophage proliferation in autocrine or paracrine fashion.
(4) HMG-CoA reductase inhibitors inhibit oxidized LDL-induced macrophage proliferation.
(5) Glucocorticoids suppress oxidized LDL-induced macrophage proliferation.
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