1999 Fiscal Year Final Research Report Summary
Cardiovascular responses to repeated partial umbilical cord occlusions in fetal sheep.
| Project/Area Number |
09671190
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
UNNO Nobuya University of Tokyo, Faculty of Medicine, Lecturer, 医学部・附属病院, 講師 (90193979)
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| Co-Investigator(Kenkyū-buntansha) |
BABA Kazunori Graduate School, The University of Tokyo, Associate Professor, 大学院・医学系研究科, 助教授 (30181035)
NISHINA Hidenori University of Tokyo, Faculty of Medicine, Assistant, 医学部・附属病院, 助手 (70251270)
KOZUMA Shiro University of Tokyo, Faculty of Medicine, Associate Professor, 医学部・附属病院, 助教授 (10272569)
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| Project Period (FY) |
1997 – 1999
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| Keywords | sheep / fetus / umbilical cord / blood flow / endocrine / circulation |
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| Research Abstract |
1. We developed a complete system for long-term chronic preparation of pregnant ewes, which enables continuous long-term monitoring of fetal blood pressure, blood flow, intrauterine pressure and myometrial electromyogram.
2. We conducted a repeated cord occlusion experiment and confirmed that long-term continuous recording is feasible in in-vivo studies.
3. We examined effects of matemally administered nitric oxide inhibitor on uterine contraction and fetal cardiovascular system and their responses to cord occlusions.
4. We studied on regulation and developmental changes in fetal hypothalamo-pituitary-adrenal axis and published papers in Biology of Reproduction and Developmental Brain Research.
5. We published a paper on the ontogenic changes in fetal cardiovascular system in American Journal of Physiology, which is essential in the study of fetal cardiovascular system in sheep.
6. We published papers on fetal endocrine cardiovascular and behavioral responses to extrauterine long-term incubation using extracorporeal membrane oxygenation via umbilical arteriovenous bypass in Pediatric Research and Biology of the Neonate.
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[Publications] Unno N, Kuwabara Y, Okai T, Kozuma S, Nakayama M, Takachi K, Masuda H, Ogami Yoshiko, Tsushima R, Ryo E, Sakai M, Kido K, Kikuchi A, Taketani Y.: "Metabolic and endocrine responses to cold exposure in chronically-incubated extrauterine goat fetuses."Pediatric Research. 43. 452-460 (1998)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Kozuma S, Nishina H, Unno N, Kagawa H, Kikuchi A, Fujii T, Baba K, Okai T, Kuwabara, Y, Taketani, Y.: "Goat fetuses disconnected from the placenta, but reconnected to an artificial placenta, display intermittent breathing movements."Biol Neonate. 75. 388-397 (1999)
Description
「研究成果報告書概要(欧文)」より
