2000 Fiscal Year Final Research Report Summary
Trace elements and their effect on ontogenic development of human
| Project/Area Number |
09671198
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
HIROSHI Nishida Tokyo Women's Medical University, Professor, 医学部, 教授 (80104553)
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| Co-Investigator(Kenkyū-buntansha) |
TAKASHIMA Sachio National Research Center for Neuroscience, Director, 所長 (70038743)
NAKABAYASHI Masao Tokyo Women's Medical University, Professor (70114585)
TAKAHASHI Naoto Tokyo Women's Medical University, Associate Professor, 医学部, 助教授 (50197159)
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| Project Period (FY) |
1997 – 2000
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| Keywords | trace element / stable isotope / neutron capture analysis / neonate / SIDS / calcium / ^<13>C breath test |
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| Research Abstract |
Initial purpose of the study was to investigate the significance of trace elements on organ development, since it is known that some of trace elements play important role of enzyme activity. Trace elements of human samples were measured by neutron capture analysis with technical assistance of Japan Atomic Energy research Institute.
Trace elements in brain samples of 5 infants who died suddenly were measured. Among several trace elements, only calcium was significantly high in SIDS group compared to non SIDS group.
Stable isotope 13C was used as a tracer to measure lever function and gastointestinal funtion of infants. 13C-Phenylalanine and 13C-Phenacetin breast test were applied to measure liver function of young infants, and13C-glycine breath test to measure gastric emptying of neonats. All methodology were proved to be safe, easy and acurate enough to use in clinical field.
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