1998 Fiscal Year Final Research Report Summary
Molecular-Biological Analysis of Outbreak Mechanism of Fetal/Neonatal Hypoxic-Ischemic Encephalopathy
| Project/Area Number |
09671201
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Fukuoka University |
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Principal Investigator |
KANEOKA Tsuyoshi Fukuoka Univ., Sch.of Medicine, Prof., 医学部, 教授 (50078755)
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| Co-Investigator(Kenkyū-buntansha) |
YUKITAKE Koh Fukuoka Univ., Sch.of Med., Assist.Prof., 医学部, 講師 (70191476)
IWAKI Toru Kyushu Univ., Fac.of Medicine, Prof., 医学部, 教授 (40221098)
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| Project Period (FY) |
1997 – 1998
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| Keywords | hypoxia-ischemia / neonatal rat brain / neuronal death / glutamate transporter / nitric oxide synthase / mRNA / fos B |
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| Research Abstract |
Seven-day-old rats were exposed to left carotid artery ligation followed by 2 hours of hypoxia (8% oxygen/92% nitrogen). Immunohistochemical studies of glial glutamate transporter(GLT1) and nitric oxide synthase (nNOS) were performed as compared with MAP2 (as a neuronal marker) and GFAP (as a glial marker). At early stage (3 hours) after ischemic injury, GLT1 expression in ischemic core was preserved in a similar to degree of the contralateral side. At 72 hours after ischemic injury, GLT1 immunoreactivity in both hippocampus and thalamus was increased in reactive astrocytes. On the contrary, nNOS immunoreactivity in ishemic side was markedly decreased following neuronal loss. Thus the glial glutamate transporter may play a role as a neuronal protector against hypoxic-ischemia in immature neonatal rat brains.
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[Publications] Hitotsumatsu, T., Iwaki, T., Kitamoto, T., Mizoguchi, M., Suzuki, O.S., Hamada, Y., Fukui, M.and Tateishi, J.: "Expression of neurofibromatosis 2 protein in human brain tumors : an immunohistochemical study." Acta Neuropathol. 93. 225-232 (1997)
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[Publications] Hamada, Y., Iwaki, T., Muratani, H., Imayama, S., Fukui M., Tateishi, J.: "Leser-Trelat sign with anaplastic ependymoma-an autopsy case." Acta Neuropathol.93. 97-100 (1997)
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[Publications] Hamada, Y., Goto, K., Inoue, T., Iwaki, T., Matsuno, H., Suzuki, S., Matsushima, T., Fukui, M., Miyake, E.: "Histopathological aspects of dural arteriovenous fistulas in the transverse-sigmoid sinus region in nine patients." Neurosurgery. 40. 452-458 (1997)
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[Publications] Yamada, T., Yoshiyama, Y., Kawaguchi, N., Ichinose, A., Iwaki, T., Hirose, S.and Jefferies W.A.: "Possible roles of transglutaminases in Alzheimer's disease." Dement.Geriatr.Cogn.Disord.9. 103-110 (1998)
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[Publications] Kawashima, T., Kikuchi, H., Takita, M., Doh-ura, K., Ogomori, K., Oda M.and Iwaki T.: "Skein-like inclusions in the neostriatum from a case of amyotrophic lateral sclerosis with dementia." Acta Neuropathol. 96. 541-545 (1998)
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