1998 Fiscal Year Final Research Report Summary
Cinical application of the evaluation of amino acid metabolism of esophageal cancer using 11C-Methionine PET
| Project/Area Number |
09671210
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | CHIBA UNIVERSITY |
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Principal Investigator |
OKAZUMI Shinichi CHIBA UNIVERSITY HOSPITAL,ASSISTANT, 医学部附属病院, 助手 (10272311)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAYAMA Wataru CHIBA UNIVERSITY HOSPITAL,ASSISTANT, 医学部附属病院, 助手 (60292702)
KOIDE Yoshio CHIBA UNIVERSITY SCHOOL OF MEDICINE LECTURER, 医学部, 講師 (80201482)
MATUBARA Hisahiro CHIBA UNIVERSITY HOSPITAL,ASSISTANT, 医学部附属病院, 助手 (20282486)
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| Project Period (FY) |
1997 – 1998
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| Keywords | 11C-METHIONINE / PET / ESOPHAGUS / CANCER / CHIMOTHERAPY |
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| Research Abstract |
Neo adjuvant therapy for esophageal cancer using CDDP and 5-FU is based on the theory of biochemical modulation by CDDP which supresses the cellular intake of methionine. In this study, we estimated the usefulness of 11 C-Methionine PET in prediction of the effect of CDDP- 5-EU for esophageal cancer.
(RESULT) Esophageal cancer showed significantly higher uptake of 11 C-Methionine than normal part of esophagus, and the uptake was related to the effect of the radiochemotherapy and also chemotherapy alone(p<0.05). 11C-Methionine PET revealed to be useful modality for the prediction of the neo adjuvant chemotherapy for esophageal cancer using CDDP and 5-FU.
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