Local Chemotherapy via Hepatic Arterial and Portal Blood Flows For Liver Cancer

1999 Fiscal Year Final Research Report Summary

• Project/Area Number: 09671286
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: GOSEKI Narihide TOKYO Medical and Dental University The First Dept. of Surgery, Associate Professor, 医学部, 助教授 (10192072)
• Co-Investigator(Kenkyū-buntansha): 岡部 聡 東京医科歯科大学, 医学部, 助手 (60242187) ; 寺本 研一 東京医科歯科大学, 医学部, 助手 (80197813)
• Project Period (FY): 1997 – 1999
• Keywords: Local Chemotherapy / Hepatic ARterial Chemotherapy / Portal Vein / Liver Cancer / Chemotherapy via Hepatic Arterial and Portal blood Flows

Research Abstract

(a) Via the hepatic artery of the rabbits inoculated VX2 tumor, ADM at a dose of 1mg/kg was administered and GSH was also infused via the portal vein at the same time (Gl(+)group (n=6)). As a control group, the rabbits were administered only ADM without GSH infusion (Gl(-)group (n=6)). Then the ADM concentrations in the liver tissue in both groups were analyzed seriously. Before and 5, 10, 15, 20, 25, 30 and 45 minutes after the ADM administration, hepatic tissue and the blood in the caval vein were sampled and measured the ADM concentration by the HPLC method.
(b) In the same models, anticancer effect in both groups were compared.
(c) (Results) (a) (1) The ADM concentrations showed the same values, with the highest in 5 to 10 minutes after ADM administration in both Gl(+) and Gl(-) groups.
(2) The ADM concentrations in the liver of Gl(+) were higher than those of Gl(-) group.
(3) There was no difference between the ADM concentrations in the blood in Gl(+) and Gl(-) groups.
(b) Median survival day of the animals in the Gl(+) group was 18.6±7.3, and that of Gl(-) was 16.4±6.3 days.