1999 Fiscal Year Final Research Report Summary
Basic and Clinical Research for dissemination of Gastric Carcinoma
| Project/Area Number |
09671324
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kagoshima University |
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Principal Investigator |
HOKITA Shuichi University Hospital, Faculty of Medicine, Kagoshima University, Assistant Professor, 医学部・附属病院, 助手 (60274833)
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| Co-Investigator(Kenkyū-buntansha) |
AIOKU Takashi Faculty of Medicine, Kagoshima University, Professor, 医学部, 教授 (60117471)
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| Project Period (FY) |
1997 – 1999
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| Keywords | gastric carcinoma / peritoneal dissemination / cytological examination / quantitative analysis of CEA / PT-PCR / prediction of recurrence |
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| Research Abstract |
Recently, the prognosis of gastric cancer became better according to improve the incidence of early gastric cancer. But the prognosis of the patient with advanced gastric cancer is still poor. Especially, gastric cancer with peritoneal dissemintation have poor prognosis. And about half of patient had been received curative resection for advanced gastric cancer, recurred peritoneal dissemination. The diagnosis and treatment of the peritoneal dissemination is very important.
In this research, we examined free cancer cell in the peritoneal cavity by cytological examination, quantitative analysis of CEA, and RT-PCR.The positive rate of the patients with peritoneal dissemination was higher than that without peritoneal dissemination. The cytological examination was negative in 55% of the patients with peritoneal dissemination. But the sensitivity of the quantitative analysis and RT-PCR was higher than that by cytological examination. It is very important that the cut off line in the quantitative analysis of CEA.94% of the patient's recurred peritoneal dissemination was positive by RT-PCR.Only 1 patient recurred peritoneal dissemination was negative by RT-PCR.The combined examination, cytological examination, quantitative analysis of CEA and RT-PCR may be useful to predict the recurrence after operation.
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