2001 Fiscal Year Final Research Report Summary
INTRAPERITONEAL ADMINISTRATION DOXORUBICIN-LOADED HYDROXYAPATITESOL IN RATS WITH AH130 PERITONEAL CARCINOMATOSIS
| Project/Area Number |
09671328
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | NAGOYA CITY UNIVERSITY |
|---|
Principal Investigator |
MOHRI Noriaki NAGOYA CITY UNIVERSITY, MEDICAL SCHOOL, Research Associate, 医学部, 助手 (60275138)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MANABE Tadao NAGOYA CITY UNIVERSITY, MEDICAL SCHOOL, PROFESSOR, 医学部, 教授 (80127141)
AKAMO Yosimi NAGOYA CITY UNIVERSITY, MEDICAL SCHOOL, Assistant Professor, 医学部, 講師 (90264720)
YOTSUYANAGI Toshihisa NAGOYA CITY UNIVERSITY, FACULTY OF PHARMACEUTICAL SCIENCE, PROFESSOR, 薬学部, 教授 (40080189)
|
|---|
| Project Period (FY) |
1997 – 1999
|
| Keywords | HYDROXYAPTITE / DOXORUBICIN / AH130 / INTRAPERITONEL ADMINISTRATION / DDS |
|---|
| Research Abstract |
(1) In vitro study, tumor cells were cultured in following 4 groups : 1)control ; 2) Hap - sol ; 3) DXR ; or 4) Hap - sol + DXR, number of tumor cells in the Hap - sol + DXR group increased least.
(2) DXR adsorbed to the Hap -sol better than 5-FU or MMC.
(3) DXR dose administered intraperitoneally in rats was deter minted to 1.5 mg/kg, adccoring to LD50 study.
|
