1998 Fiscal Year Final Research Report Summary
Immunoguided Surgery Using Monoclonal Antibody A7 Coupled to Magnetic Particles
| Project/Area Number |
09671329
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Kyoto Prefectural University of Medicine |
|---|
Principal Investigator |
OTSUJI Eigo Kyoto Prefectural University of Medicine, School of Medicine, Department of Surgery, Assistant Professor, 医学部, 助手 (20244600)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OKAMOTO Kazuma Kyoto Prefectural University of Medicine, School of Medicine, Department of Surg, 医学部, 助手 (20285258)
|
|---|
| Project Period (FY) |
1997 – 1998
|
| Keywords | MONOCLONAL / ANTIBODY / A7 / PANCREATIC CANCER |
|---|
| Research Abstract |
We examined the retaining in vitro immunoreactivity of ferromagnetic particles bound to Mab A7 and their in vivo distribution in nude mice bearing human pancreatic carcinoma xenografts were examined. A7-Lignosite FML retained binding activities nearly identical to Mab A7. Significantly more of the radiolabeled A7-Lignosite FML accumulated in the tumor than did normal mouse IgG-Lignosite FML (P<0.05). A7-Lignosite FML and ^<125>I labeled normal mouse IgG-Lignosite FML disappeared from blood rapidly. As for all resected normal tissues, the accumulation levels of ^<125>I labeled A7-Lignosite FML were lower than those for the tumors and decreased linearly with time.
|
