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1998 Fiscal Year Final Research Report Summary

Strategy for hepatocellular carcinoma from the view point of viral status

Research Project

Project/Area Number 09671330
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionOsaka City University Medical School

Principal Investigator

KUBO Shoji  Second Department of Surgery, Osaka City University Medical School, 医学部, 講師 (80221224)

Co-Investigator(Kenkyū-buntansha) NISHIGUCHI Shuhei  Third Department of Internal Medicine, Osaka City University Medical School, 医学部, 講師 (10192246)
Project Period (FY) 1997 – 1998
KeywordsHepatocellular carcinoma / Liver resection / Hepatitis B virus / Hepatitis C virus / Hepatitis G virus
Research Abstract

Serum markers for Hepatitis B and/or C virus were detected in about 97% of patients who underwent liver resection for hepatocellular carcinoma (HCC) in our department. In 1 % of the patients, hepatitic B virus gene was detected in HCC tissue. Hepatitis G virus RNA was detected in sera in 12 of 213 patients. The 12 patients also had serum markers for hepatitis B virus (HBV) or hepatitis C virus (HCV), indicating that the hepatitis G virus has poor association with HCC.The age was younger in patients infected with HBV than in patients infected with HCV.The tumor size was larger in patients infected with HBV than in patients infected with HCV.The amount of HBV sometimes increased after operation, followed by increase in alanine aminotransferase activity, in patients with wild-type HBV and large amount of HBV.In patients infected with HBV, the risk factors for recurrence included low platelet count, wild-type HBV, high viral load, positive surgical margin, and nonantomic resection. In patients infected with HCV, the risk factors included high age, positive serum HCV RNA, high activities of alanine and aspartate aminotransferase, larged tumor size (more than 4cm), multiple tumors, and portal invasion. Interferon therapy after resection of HCC may be useful to prevent recurrence. Extended resection (anatomic resection) is indicated for patients infected with HBV.For patients infected with HCV, not only complete resection of HCC but a1so strategy for HCV are necessary.

  • Research Products

    (25 results)

All Other

All Publications (25 results)

  • [Publications] S.Kubo,etal.: "High maligncmy of leplto collulan carcinamain in alcholic patiemts with heptitis cvius" Surgery. 121(4). 425-429 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Kubo,etal.: "Poor association of GBV-C viremia with hepartocllula caruima" J. Hepctology. 27. 91-95 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Kubo,etal.: "Development of hepato celhlan carainona in potients with HCV infection with orvithary pant HBV infetm.and nelrtioship to age at the time of transfusim" Vox Song. 74(2). 129 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 首藤太一 他: "同時性多発肝細胞癌に対する手術用式とその成績" 日本外科系連合学会雑誌. 23(1). 69-74 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Kubo,etal.: "Ettet of rlcohlabase or pdyawire nufabolism in beputoablela carcion and noncamceros hepati tissul" Sunguy. 123(2). 205-211 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Kubo,etal.: "Climiophatholoyi cal crtria for muilticentncity of hipatocellbla coucinoms and nskfaihrs for such caiainogeneses" Jpn.J Coma Res.189(4). 419-426 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Shuto,etal.: "Changes and results of surgicl stantegies for hepitucollalci coucions results of a 15-year study on 452comsewtire oatisuts." Sunguy Today. 28(11). 1124-1129 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Shuto,etal: "Ditterancis of reseitsd hepatoalbddar coraimama with B or C uirus" Hepatoyastro cuteralogySunguy. 45. 1722-1725 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 木下博明 他: "肝細胞癌治療の変遷" 消化器外科. 21(4). 403-407 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 久保正二 他: "肝炎ウイルス病態からみた肝細胞癌治療戦略" 消化器外科. 21(4). 425-430 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 榎本大 他: "G型肝炎ウイルス感染の診断と病態" 臨床科学. 33(8). 940-944 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 榎本大 他: "G型肝硬変.肝癌はあるのか?" Modern Physician. 17(9). 1115-1117 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 木下博明: "肝臓の手術の変遷と将来" 消化器外科. 21(13). 2100-2104 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Kubo, H.Kinoshita, K.Hirohashi, H.Tanaka, T.Tsukamoto, T.Shuto, T.Kuroki: "High malignancy of hepatocellular carcinoma in alcholic patients with hepatitis C virus." Surgery. 121 (4). 425-429 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Kubo, S.Nishiguchi, T.Kuroki, K.Hirohashi, H.Tanaka, T.Tsukamoto, T.Shuto, H.Kinoshita: "Poor association of GBV-C viremia with hepatocellular carcinoma." J.Hepatology. 27. 91-95 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Kubo, H.Kinoshita, K.Hirohashi, H.Tanaka, T.Tsukamoto, T.Shuto, Y.Morimoto, A.Kanazawa, S.Mikami, C.Sakata: "The efficacy of preoperative portal vein embolization prior to a major hepatectomy for patients with an impaired liver function : A retrospective study." J.Hep.Bil.Panc.Surg.4. 359-364 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Kubo, S.Nishiguchi, A.Tamori, K.Hirohashi, H.Kinoshita, T.Kuroki: "Development of Hepatocellular Carcinoma in Patients with HCV Infection, with or without Past HBV Infection, and Relationship to Age at the Time of Transfusion." Vox Sang. 74 (2). 129 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Shuto, K,Hirohashi, S.Kubo, H.Tanaka, T.Tsukamoto, H.Hamba, S.Mikami, T.Yamamoto, T.Ikebe, H.Kinoshita: "Surgical treatment and results for simultaneous multiple hepatocellular carcinoma." J.Jpn.Colledge Surg.23 (1). 69-74 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Kubo, A.Tamori, S.Nishiguchi, H.Kinoshita, K.Hirohashi, T.Kuroki, Y.Omura, S.Otani: "Effect of alcohol abuse on polyamine metabolism in hepatocellular carcinoma and noncancerous hepatic tissue." Surgery. 123 (2). 205-211 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Kubo, S.Nishiguchi, K.Hirohashi, T.shuto, T.Kuroki, S.Minamitani, T.Ikebe, T.Yamamoto, K.Wakasa, H.kinoshita: "Clinicopathological criteria for multicentricity of hepatocellular carcinoma and risk factors for such carcinogenesis." Jpn.J.Cancer Res.89 (4). 419-426 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Shuto, K.Hirohashi, S.Kubo, H.Tanaka, T.Tsukamoto, T.Yamamoto, T.Ikebe, H.Kinoshita: "Changes and results of surgical strategies for hepatocellulr carcinoma : results of a 15-year study on 452 consecutive patients." Surgery Today. 28 (11). 1124-1129 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Shuto, K.Hirohashi, S.Kubo, T.Tsukamoto, T.Yamamoto, K.Wakasa, H.Kinoshita: "Differences of resected hepatocellular carcinoma with hepatitis B or C virus." Hepatogastroenterology. 45. 1722-1725 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Kinoshita, T.Shuto, S.Kubo, K.Hirohshi: "Advances in tretament for hepatocellular carcinoma" Gastroenterological Surgery. 21 (4). 403-407 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Kubo, K.Hirohashi, T.Tanaka, H.Hamba, T.Shuto, T.Okuda, S.Nishiguchi, A.Tamori, T.Kuroki, H.Kinoshita: "Strategy for hepatocellular carcinoma according to the state of hepatitis viral infection." Gastroeterological Surgery. 21 (4). 425-430 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Kinoshita, T.Shuto, S.Takemura, S.Kubo, K.Hirohashi: "Histroy and prospective problems of liver surgery." Gastroeterological Surgery. 21 (13). 2100-2104 (1998)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-12-08  

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