1998 Fiscal Year Final Research Report Summary
ANGIOGENESIS AND MONOCLONAL ANTIBODY UPTAKE IN MICROMETASTASES OF THE LIVER
| Project/Area Number |
09671337
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | THE JIKEI UNIVERSITY SCHOOL OF MEDICINE |
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Principal Investigator |
YOSHIDA Kazuhiko THE JIKEI UNIVERSITY SCHOOL OF MEDICINE,LECTURER, 外科学講座・第1, 講師 (90191577)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Kazumi THE JIKEI UNIVERSITY SCHOOL OF MEDICINE,STAFFS, 外科学講座・第1, 助手 (50287306)
MISAWA Takeyuki THE JIKEI UNIVERSITY SCHOOL OF MEDICINE,STAFFS, 外科学講座・第1, 助手 (50260956)
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| Project Period (FY) |
1997 – 1998
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| Keywords | monoclonal antibody / colon cancer / liver metastasis |
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| Research Abstract |
To determine the relationship between angiogenesis and monoclonal antibody (mAb) uptake in micrometastases, we made a model of hepatic micrometastases after splenic injection of human colon cancer cell (HT-29) in nude mice, and analyze the angiogenesis and mAb (H-15) uptake in the model. In micrometastases which size were between 300*600 mum, a plenty of angiogenesis was found and high accumulation of mAb was identified around newer vessels. This information is very useful to conduct clinical trials of radioimmunotherapy in adjuvant setting.
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