1998 Fiscal Year Final Research Report Summary
Development of vascular protheses for a child-expansion after long term implantation
| Project/Area Number |
09671388
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | KYOTO PREFECTURAL UNIVERSITY OF MEDICINE |
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Principal Investigator |
SATOH Shinichi SATOH,Shinichi, 医学部, 講師 (30178735)
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| Project Period (FY) |
1997 – 1998
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| Keywords | percutaneous angioplasty / neointimal formation |
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| Research Abstract |
Vascular prostheses implanted in growing children may cause serious hemodynamic disturbance, when they become too small in diameter comparing to the grown native arteries. We have developed vascular prostheses which can be dilated by a percutaneous transluminal angioplasty (PTA) at a given time to compensate such discrepancy in diameter. The prosthesis was made of woven polyester fiber fabrics, the circumferential yarns of which consist of two different types of polyester fiber bundles. We have reported that the prostheses were successfully dilated with the use of PTA balloon in vitro and in the short term animal experiment as well. In this study, the prostheses with the initial diameter of 6mm were implanted to descending thoracic aortae (8-10mm in diameter) of mongrel dogs for 18 months as a longer term evaluation. After 18 month-implantation, with the use of PTA ballooning of 15 ATM, implanted grafts were dilated to 9mm in diameter which was maintained after 30 days. No bleeding, hematoma or pseudo-aneurysmal formation were observed. In conclusion, the newly developed grafts could be safely dilated after implantation in vivo.
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